ArticleCommunications biology2024
Stomach as the target organ of Rickettsia heilongjiangensis infection in C57BL/6 mice identified by click chemistry.
Juan Wang, Li-Feng Du, Ming-Zhu Zhang, Wei Wei, Zi-Yun Chen, Xu Zhang, Tao Xiong, Zhen-Fei Wang, Luo-Yuan Xia, Jia-Fu Jiang and 4 more
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In one paragraphArticle in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
Juan WangSchool of Public Health and Health Management, Gannan Medical University, Ganzhou, 341000, Jiangxi, P. R. China.ORCID 0009-0005-0147-1044 Li-Feng DuInstitute of EcoHealth, School of Public Health, Shandong University, 44 Wenhuaxi Street, Jinan, 250012, Shandong, P.R. China.
Ming-Zhu ZhangInstitute of EcoHealth, School of Public Health, Shandong University, 44 Wenhuaxi Street, Jinan, 250012, Shandong, P.R. China.
Wei WeiState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, P.R. China.
Zi-Yun ChenState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, P.R. China.
Xu ZhangGuangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of Biomaterials, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations Shenzhen Institute of Advanced Technology (SIAT) Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
Tao XiongState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, P.R. China.
Zhen-Fei WangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Luo-Yuan XiaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, P.R. China.ORCID 0000-0002-1656-3401 Jia-Fu Jiang *State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, P.R. China. jiangjf2008@gmail.com.ORCID 0000-0002-4784-8813 Wen-Jun Li *Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of Biomaterials, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations Shenzhen Institute of Advanced Technology (SIAT) Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. wj.li@siat.ac.cn.ORCID 0000-0003-1458-7466 Dai-Yun Zhu *State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, P.R. China. 549225561@qq.com.ORCID 0000-0002-6825-5806 Na Jia *State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, P.R. China. jiana79_41@hotmail.com.ORCID 0000-0003-0532-7064 Wu-Chun Cao *State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, P.R. China. caowuchun@126.com.ORCID 0000-0002-5090-2251 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Spotted fever group rickettsiae (SFGR) are obligate intracellular bacteria that cause spotted fever. The limitations of gene manipulation pose great challenges to studying the infection mechanisms of Rickettsia. By combining bioorthogonal metabolism and click chemistry, we developed a method to label R. heilongjiangensis via azide moieties and achieved rapid pathogen localization without complex procedures. Moreover, we constructed a C57BL/6 mice infection model by simulating tick bites and discovered that the stomach is the target organ of R. heilongjiangensis infection through in vivo imaging systems, which explained the occurrence of gastrointestinal symptoms following R. heilongjiangensis infection in some cases. This study offers a unique perspective for subsequent investigations into the pathogenic mechanisms of SFGR and identifies a potential target organ for R. heilongjiangensis.
Indexed as
Click ChemistryMice, Inbred C57BLRickettsiaAnimalsAzidesDisease Models, AnimalFemaleMiceRickettsia InfectionsSpotted Fever Group RickettsiosisStomachAzides
Identifiers
PMID38951577
PMCPMC11217389
What OpenQuestion holds
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LicenceCC BY
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