Evidence map›Paper›PMID 38951546›Full record

ArticleScientific reports2024

Exposure to Gulf war illness-related chemicals exacerbates alcohol-induced liver damage in rodents.

Anca D Petrescu, Juliet Venter, Daria D Danilenko, Daniela Medina, Stephanie Grant, Su Yeon An, Elaina Williams, Patrick Mireles, Kathryn Rhodes, Matthew Tjahja and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Anca D PetrescuDivision of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA.
Juliet VenterDivision of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA.
Daria D DanilenkoDivision of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA.
Daniela MedinaDepartment of Health and Societies, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Stephanie GrantDivision of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA.
Su Yeon AnDivision of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA.
Elaina WilliamsDivision of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA.
Patrick MirelesDivision of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA.
Kathryn RhodesDivision of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA.
Matthew TjahjaDepartment of Internal Medicine, Baylor Scott & White Health, Temple, TX, 76502, USA.
Sharon DeMorrowDivision of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA. sharon.demorrow@austin.utexas.edu.

Funding

Dysregulation of hypothalamic neuropeptides is associated with biliary hyperplasiaR01DK082435 · NIDDK · UNIVERSITY OF TEXAS AT AUSTIN · PI DEMORROW, SHARON · 2010 to 2020
$2.7M
Molecular mechanisms of drug-induced liver injuryR01DK112803 · NIDDK · UNIVERSITY OF TEXAS AT AUSTIN · PI DEMORROW, SHARON · 2018 to 2021
$1.4M
The role of hypothalamic neuropeptides on biliary function during cholestasisI01BX002638 · VA · OLIN TEAGUE VETERANS CENTER · PI DEMORROW, SHARON · 2015 to 2018
–
BLRD VA I01 BX002638NIDDK NIH HHS DK082435NIDDK NIH HHS DK112803NIDDK NIH HHS R01 DK082435NIDDK NIH HHS R01 DK112803U.S. Department of Veterans Affairs BX002638
6 · The paper itself

Abstract

Gulf War Illness (GWI) describes a series of symptoms suffered by veterans of the Gulf war, consisting of cognitive, neurological and gastrointestinal dysfunctions. Two chemicals associated with GWI are the insecticide permethrin (PER) and the nerve gas prophylactic pyridostigmine-bromide (PB). In this study we assessed the effects of PER and PB exposure on the pathology and subsequent alcohol (EtOH)-induced liver injury, and the influence of a macrophage depletor, PLX3397, on EtOH-induced liver damage in PER/PB-treated mice. Male C57BL/6 mice were injected daily with vehicle or PER/PB for 10 days, followed by 4 months recovery, then treatment with PLX3397 and a chronic-plus-single-binge EtOH challenge for 10 days. PER/PB exposure resulted in the protracted increase in liver transaminases in the serum and induced chronic low-level microvesicular steatosis and inflammation in GWI vs Naïve mice up to 4 months after cessation of exposure. Furthermore, prior exposure to PER/PB also resulted in exacerbated response to EtOH-induced liver injury, with enhanced steatosis, ductular reaction and fibrosis. The enhanced EtOH-induced liver damage in GWI-mice was attenuated by strategies designed to deplete macrophages in the liver. Taken together, these data suggest that exposure to GWI-related chemicals may alter the liver's response to subsequent ethanol exposure.

Indexed as

EthanolMice, Inbred C57BLPersian Gulf SyndromePyridostigmine BromideAnimalsDisease Models, AnimalInsecticidesLiverMaleMicePermethrinEthanolInsecticidesPermethrinPyridostigmine Bromide

Identifiers

PMID38951546
PMCPMC11217429

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.