Evidence map›Paper›PMID 38951528›Full record

ArticleNPJ Parkinson's disease2024

Increased mean diffusivity of the caudal motor SNc identifies patients with REM sleep behaviour disorder and Parkinson's disease.

Erind Alushaj, Dimuthu Hemachandra, Hooman Ganjavi, Ken N Seergobin, Manas Sharma, Alia Kashgari, Jennifer Barr, William Reisman, Ali R Khan, Penny A MacDonald

Abstract read
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In one paragraph

Article in NPJ Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Erind AlushajDepartment of Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Dimuthu HemachandraRobarts Research Institute, Western University, London, ON, Canada.
Hooman GanjaviDepartment of Psychiatry, Western University, London, ON, Canada.
Ken N SeergobinWestern Institute for Neuroscience, Western University, London, ON, Canada.
Manas SharmaDepartment of Radiology, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0003-0947-1282
Alia KashgariDepartment of Medicine, Respirology Division, Western University, London, ON, Canada.ORCID http://orcid.org/0009-0007-4505-2081
Jennifer BarrDepartment of Psychiatry, Western University, London, ON, Canada.
William ReismanDepartment of Medicine, Respirology Division, Western University, London, ON, Canada.
Ali R KhanRobarts Research Institute, Western University, London, ON, Canada.
Penny A MacDonaldWestern Institute for Neuroscience, Western University, London, ON, Canada. penny.macdonald@gmail.com.ORCID http://orcid.org/0000-0002-1817-2383

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) 201903
6 · The paper itself

Abstract

Idiopathic rapid eye movement sleep behaviour disorder (iRBD)-a Parkinson's disease (PD) prodrome-might exhibit neural changes similar to those in PD. Substantia nigra pars compacta (SNc) degeneration underlies motor symptoms of PD. In iRBD and early PD (ePD), we measured diffusion MRI (dMRI) in the caudal motor SNc, which overlaps the nigrosome-1-the earliest-degenerating dopaminergic neurons in PD-and in the striatum. Nineteen iRBD, 26 ePD (1.7 ± 0.03 years), and 46 age-matched healthy controls (HCs) were scanned at Western University, and 47 iRBD, 115 ePD (0.9 ± 0.01 years), and 56 HCs were scanned through the Parkinson's Progression Markers Initiative, using 3T MRI. We segmented the SNc and striatum into subregions using automated probabilistic tractography to the cortex. We measured mean diffusivity (MD) and fractional anisotropy (FA) along white-matter bundles and subregional surfaces. We performed group-level and classification analyses. Increased caudal motor SNc surface MD was the only iRBD-HCs and ePD-HCs difference replicating across datasets (p

Identifiers

PMID38951528
PMCPMC11217278

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.