ArticleNature communications2024
IFNγ-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17citing papers in PubMed, 1 pooled it
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping the knowledge domains of literature on hepatocellular carcinoma and liver failure: a bibliometric approach.Frontiers in oncology · 2025Pooled it
- Hepatic fibrosis extracellular matrix stiffness induces abnormal maturation of dendritic cell via AMPK inhibition-mediated cholesterol accumulation.Materials today. Bio · 2026Article
- ACSS2-KAT5 complex-driven histone crotonylation orchestrates a pro-inflammatory program to promote the transition from MASLD to MASH.Nature communications · 2026Article
- GraphBAN-based identification of active ingredients and key gene targets in compound Chinese herbal medicines for polycystic ovary syndrome.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Differences in gene expression may contribute to the racial differences in the risk of MASLD.PloS one · 2026Article
- Integrative and interpretable machine learning framework for early non-invasive detection of clinically significant liver fibrosis.Frontiers in medicine · 2026Article
- Reduced circulating mitochondrial DNA integrity and increased DNA oxidation in preclinical and clinical pediatric obesity: an observational study.Frontiers in pediatrics · 2026Article
- Evaluation of the Immortalized Primary Human Hepatocyte Cell Line Fa2N-4 as a Model for Metabolic Dysfunction-Associated Steatotic Liver Disease.Gastro hep advances · 2026Article
- Exploring the Systemic Immune-Inflammation Index as a novel biomarker for nonalcoholic fatty liver disease: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2025Article
- Avian GCGR-mediated continuous fat utilization offers perspectives for obesity treatment.Nature communications · 2025Article
- Integrated profiling of adiponectin and cytokine signaling pathways in high-fat diet-induced MASLD reveals early markers of disease progression.Scientific reports · 2025Article
- Longitudinal multi-omics analysis of the gut-liver axis: Unraveling the molecular mechanisms of metabolic homeostasis regulation by Pd@Pt nanozymes.Materials today. Bio · 2025Article
- TRIM25-Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- TIPE2 deficiency amplifies inflammation and immune dysregulation in MASH through modulating hepatic lipid metabolism and immune cell function.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Association between triglyceride-glucose and triglyceride-glucose related indices with all-cause mortality in depression participants: a cohort study from NHANES.Frontiers in psychiatry · 2025Article
- Clinical metabolomics in type 2 diabetes mellitus: from pathogenesis to biomarkers.Frontiers in endocrinology · 2025Review
- Macrophage-tregs crosstalk: the "hub" of the immune network in MASLD.Frontiers in immunology · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
31 authors.
Randall H FriedlineProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-0894-448X
Hye Lim NohProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Sujin SukProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Mahaa AlbusharifProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Sezin DagdevirenProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-0740-3481
Suchaorn SaengnipanthkulProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-1368-9508
Bukyung KimProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Allison M KimProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Lauren H KimProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Lauren A TauerProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-2315-1050
Natalie M Baez TorresProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Stephanie ChoiProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Bo-Yeon KimProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Suryateja D RaoProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Kaushal KasinaProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Cheng SunDivision of Gastroenterology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Benjamin J TolesDivision of Gastroenterology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Chan ZhouDivision of Biostatistics and Health Services Research, Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-0351-6235
Zixiu LiDivision of Biostatistics and Health Services Research, Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Vivian M BenoitProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Payal R PatelProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Doris X T ZhengProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Kunikazu InashimaProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Annika BeaversonProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Xiaodi HuProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Duy A TranProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Werner MullerDivision of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, United Kingdom.ORCID 0000-0002-1297-9725
Dale L GreinerProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Alan C MullenDivision of Gastroenterology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-4096-3106
Ki Won LeeWCU Biomodulation Major, Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.
Jason K KimProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. jason.kim@umassmed.edu.ORCID 0000-0002-7185-042X
Funding
University of Massachusetts Center for Clinical Science and Translational SupplementUL1TR001453 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2015 to 2024
$39.0MLong noncoding RNAs regulating liver fibrosisR01DK116999 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALAN C MULLEN · 2019 to 2026
$2.2MRole of Interferon-Gamma / Interleukin-12 Axis in Metabolic Liver DiseaseR01DK133772 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI JASON K KIM · 2023 to 2026
$1.9MNCATS NIH HHS UL1 TR001453NIDDK NIH HHS R01 DK116999NIDDK NIH HHS R01 DK133772U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health) R01DK133772U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK116999
Abstract
Obesity is a major cause of metabolic dysfunction-associated steatohepatitis (MASH) and is characterized by inflammation and insulin resistance. Interferon-γ (IFNγ) is a pro-inflammatory cytokine elevated in obesity and modulating macrophage functions. Here, we show that male mice with loss of IFNγ signaling in myeloid cells (Lyz-IFNγR2
Indexed as
Fatty LiverInsulin ResistanceInterferon-gammaInterleukin-12LiverMacrophagesMice, KnockoutObesitySignal TransductionAnimalsDiet, High-FatInterferon gamma ReceptorLiver CirrhosisMaleMiceMice, Inbred C57BLInterferon-gammaInterferon gamma ReceptorInterleukin-12Receptors, Interferon
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