Evidence map›Paper›PMID 38951450›Full record

ArticleMolecular biology reports2024

Kaempferia parviflora extract and its component polymethoxyflavones suppress adipogenic differentiation of human bone marrow-derived mesenchymal stem cells via the AMPK pathway.

Masakazu Ishii, Haruka Miyata, Nao Ikeda, Tomoaki Sakurai, Yurika Oura, Masahiro Nishimura

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Oral delivery ofInternational journal of pharmaceutics: X · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Masakazu IshiiDepartment of Oral and Maxillofacial Prosthodontics, Kagoshima University Graduate School of Medical and Dental Science 8-35-1, Sakuragaoka, Kagoshima, Japan. k2583381@kadai.jp.
Haruka MiyataDepartment of Oral and Maxillofacial Prosthodontics, Kagoshima University Graduate School of Medical and Dental Science 8-35-1, Sakuragaoka, Kagoshima, Japan.
Nao IkedaDepartment of Oral and Maxillofacial Prosthodontics, Kagoshima University Graduate School of Medical and Dental Science 8-35-1, Sakuragaoka, Kagoshima, Japan.
Tomoaki SakuraiDepartment of Oral and Maxillofacial Prosthodontics, Kagoshima University Graduate School of Medical and Dental Science 8-35-1, Sakuragaoka, Kagoshima, Japan.
Yurika OuraDepartment of Oral and Maxillofacial Prosthodontics, Kagoshima University Graduate School of Medical and Dental Science 8-35-1, Sakuragaoka, Kagoshima, Japan.
Masahiro NishimuraDepartment of Oral and Maxillofacial Prosthodontics, Kagoshima University Graduate School of Medical and Dental Science 8-35-1, Sakuragaoka, Kagoshima, Japan.

Funding

JSPS KAKENHI 21K10005JSPS KAKENHI JP23H03095
6 · The paper itself

Abstract

backgroundKaempferia parviflora Wall. ex. Baker (KP) has been reported to exhibit anti-obesity effects. However, the detailed mechanism of the anti-obesity effect of KP extract (KPE) is yet to be clarified. Here, we investigated the effect of KPE and its component polymethoxyflavones (PMFs) on the adipogenic differentiation of human mesenchymal stem cells (MSCs). METHODS AND

resultsKPE and PMFs fraction (2.5 µg/mL) significantly inhibited lipid and triacylglyceride accumulation in MSCs; lipid accumulation in MSCs was suppressed during the early stages of differentiation (days 0-3) but not during the mid (days 3-7) or late (days 7-14) stages. Treatment with KPE and PMFs fractions significantly suppressed peroxisome proliferator-activated receptor-γ (PPARγ), CCAAT/enhancer binding protein α (C/EBPα), and various adipogenic metabolic factors. Treatment with KPE and PMFs fraction induced the activation of AMP-activated protein kinase (AMPK) signaling, and pretreatment with an AMPK signaling inhibitor significantly attenuated KPE- and PMFs fraction-induced suppression of lipid formation.

conclusionsOur findings demonstrate that KPE and PMFs fraction inhibit lipid formation by inhibiting the differentiation of undifferentiated MSCs into adipocyte lineages via AMPK signaling, and this may be the mechanism underlying the anti-obesity effects of KPE and PMFs. Our study lays the foundation for the elucidation of the anti-obesity mechanism of KPE and PMFs.

Indexed as

AdipogenesisAMP-Activated Protein KinasesCell DifferentiationFlavonesMesenchymal Stem CellsPlant ExtractsSignal TransductionZingiberaceaeAdipocytesCells, CulturedHumansPPAR gammaAMP-Activated Protein KinasesFlavonesPlant ExtractsPPAR gammaAdipogenic differentiationAMPKAnti-obesityKaempferia parviflora Wall. ex. BakerMesenchymal stem cellsPolymethoxyflavones

Identifiers

PMID38951450

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.