Evidence map›Paper›PMID 38951365›Full record

ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2025

Early-onset pancreatic cancer and associated metabolic risk factors in the Middle East and North Africa: A 20-year analysis of the Global Burden of Disease Study.

Pojsakorn Danpanichkul, Ekdanai Uawithya, Chawin Lopimpisuth, Banthoon Sukphutanan, Narathorn Kulthamrongsri, Majd B Aboona, Kwanjit Duangsonk, Sirimas Lau, Daniel M Simadibrata, Hinda Daggag and 2 more

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Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pojsakorn DanpanichkulDepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA. pojsakorndan@gmail.com.ORCID 0000-0002-9121-165X
Ekdanai UawithyaFaculty of Medicine Siriraj Hospital, Mahidol University, Nakhon Pathom, Thailand.
Chawin LopimpisuthDepartment of Internal Medicine, University of Miami, Jackson Memorial Hospital, Miami, FL, USA.
Banthoon SukphutananFaculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Narathorn KulthamrongsriDepartment of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Nakhon Pathom, Thailand.
Majd B AboonaDepartment of Internal Medicine, University of Arizona College of Medicine, Phoenix, AZ, USA.
Kwanjit DuangsonkDepartment of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Sirimas LauDepartment of Internal Medicine, Metrowest Medical Center, Framingham, MA, USA.
Daniel M SimadibrataFaculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Hinda DaggagImperial College London Diabetes Centre, Abu Dhabi, United Arab Emirates.
Michael B WallaceDivision of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.
Karn WijarnpreechaDivision of Gastroenterology and Hepatology, Department of Medicine, University of Arizona College of Medicine, Phoenix, AZ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveEarly-onset pancreatic cancer (EOPC) is associated with poor prognosis and high disease burden. Metabolic risk factors such as diabetes and obesity are considered risk factors of EOPC. Recently, there has been an increasing number of EOPCs worldwide. However, the analysis of EOPC, including its metabolic risk factors, in the Middle East and North Africa (MENA) region has not been fully addressed.

methodsData from the Global Burden of Disease Study between 2000 and 2019 was used to analyze the prevalence, incidence, deaths and disability-adjusted life years (DALYs) associated with EOPC and its metabolic risk factors. The analysis further categorized the data based on countries, income status and sex and examined the annual percentage change (APC).

resultsApproximately 2800 cases, 2400 deaths and 114,000 DALYs were attributable to EOPC in the MENA region. The incidence (APC + 3.42%), death (APC + 0.73%) and DALYs (APC + 3.23%) rates of EOPC increased. In addition, the death and DALY rates of EOPC attributable to obesity and diabetes increased. High and upper-middle-income countries exhibited a higher burden of EOPC than lower-income countries.

conclusionOver the past two decades, the burden of EOPC and its associated metabolic risk factors has increased. There is an urgent need for region-wide policy development, including screening methods and risk factor reduction, to mitigate the high and rising burden of EOPC in the MENA region.

Indexed as

ObesityPancreatic NeoplasmsAdultAfrica, NorthernAge of OnsetDiabetes MellitusDisability-Adjusted Life YearsFemaleGlobal Burden of DiseaseHumansIncidenceMaleMiddle AgedMiddle EastPrevalenceRisk FactorsEarly-onset cancerEpidemiologyMiddle EastPancreatic cancer

Identifiers

PMID38951365

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.