Evidence map›Paper›PMID 38951317›Full record

ArticleMikrochimica acta2024

A sensitive gold nanoflower-based lateral flow assay coupled with gold staining technique for the detection of SARS-CoV-2 antigen.

Rushi Liang, Feiqian Wang, Shanshan Li, Yajing Niu, Yinuo Sun, Sile Hong, Aiping Fan

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rushi LiangSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin300072, PR China.
Feiqian WangSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin300072, PR China.
Shanshan LiSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin300072, PR China.
Yajing NiuBeijing Pharma and Biotech Center, Beijing, 100035, PR China.
Yinuo SunSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin300072, PR China.
Sile HongSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin300072, PR China.
Aiping FanSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin300072, PR China. fanap@tju.edu.cn.ORCID http://orcid.org/0000-0002-0875-710X

Funding

National Natural Science Foundation of China 21475094
6 · The paper itself

Abstract

An enhanced lateral flow assay (LFA) is presented for rapid and highly sensitive detection of acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antigens with gold nanoflowers (Au NFs) as signaling markers and gold enhancement to amplify the signal intensities. First, the effect of the morphology of gold nanomaterials on the sensitivity of LFA detection was investigated. The results showed that Au NFs prepared by the seed growth method showed a 5-fold higher detection sensitivity than gold nanoparticles (Au NPs) of the same particle size, which may benefit from the higher extinction coefficient and larger specific surface area of Au NFs. Under the optimized experimental conditions, the Au NFs-based LFA exhibited a detection limit (LOD) of 25 pg mL

Indexed as

Antigens, ViralCoronavirus Nucleocapsid ProteinsGoldLimit of DetectionMetal NanoparticlesSARS-CoV-2COVID-19COVID-19 Serological TestingHumansImmunoassayPhosphoproteinsAntigens, ViralCoronavirus Nucleocapsid ProteinsGoldnucleocapsid phosphoprotein, SARS-CoV-2PhosphoproteinsGold nanoflowersGold staining technologyLateral flow assayN proteinSevere acute respiratory syndrome coronavirus-2

Identifiers

PMID38951317

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.