Evidence map›Paper›PMID 38951247›Full record

ArticleArchives of dermatological research2024

Plasma proteins and inflammatory dermatoses: proteome-wide Mendelian randomization and colocalization analyses.

Mengsong Liu, Mulan Chen, Junwen Tan, Anjing Chen, Jing Guo

Abstract read
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In one paragraph

Article in Archives of dermatological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mengsong LiuSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Mulan ChenSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Junwen TanSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Anjing ChenSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Jing GuoSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China. guojing66@cdutcm.edu.cn.

Funding

National Natural Science Foundation of China 82074443
6 · The paper itself

Abstract

Current genome-wide association studies (GWAS) of plasma proteomes provide additional possibilities for finding new drug targets for inflammatory dermatoses. We performed proteome-wide Mendelian randomization (MR) and colocalization analyses to identify novel potential drug targets for inflammatory dermatoses. We performed MR and colocalization analysis using genetic variation as instrumental variables to determine the causal relationship between circulating plasma proteins and inflammatory dermatoses. 5 plasma proteins were found to be causally associated with dermatitis eczematosa, SLE, urticaria and psoriasis using cis-pQTLs as instrumental variables, but not found in AD and LP. 19 candidate genes with high colocalization evidence were identified. These potential drug targets still require more research and rigorous validation in future trials.

Indexed as

Blood ProteinsGenome-Wide Association StudyMendelian Randomization AnalysisProteomeGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotidePsoriasisQuantitative Trait LociBlood ProteinsProteomeAtopic dermatitisColocalization analysisDermatitis eczematosaLichen planusMendelian randomizationPlasma proteomePsoriasisSystemic lupus erythematosusUrticaria

Identifiers

PMID38951247

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.