Evidence map›Paper›PMID 38951151›Full record

ArticleNutrition & diabetes2024

First-trimester hemoglobin, haptoglobin genotype, and risk of gestational diabetes mellitus in a retrospective study among Chinese pregnant women.

Yue Li, Fang Wang, Xinmei Huang, Shuhang Zong, Yi Shen, Lina Guo, Qiongyi Cai, Tiange Sun, Rui Zhang, Zhiyan Yu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yue Li *Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, 200240, Shanghai, China.ORCID 0000-0001-5603-104X
Fang Wang *Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, 200240, Shanghai, China.
Xinmei HuangDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, 200240, Shanghai, China.
Shuhang ZongDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, 200240, Shanghai, China.
Yi ShenDepartment of Obstetrics and Gynecology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, 200240, Shanghai, China.
Lina GuoDepartment of Obstetrics and Gynecology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, 200240, Shanghai, China.
Qiongyi CaiDepartment of Obstetrics and Gynecology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, 200240, Shanghai, China.
Tiange SunDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, 200240, Shanghai, China.
Rui ZhangDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, 200240, Shanghai, China.
Zhiyan YuDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, 200240, Shanghai, China.
Liwen ZhangDepartment of Obstetrics and Gynecology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, 200240, Shanghai, China. 13321837079@163.com.
Shufei ZangDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, 200240, Shanghai, China. sophiazsf@fudan.edu.cn.
Jun LiuDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, 200240, Shanghai, China. liu__jun@fudan.edu.cn.ORCID 0000-0002-4222-7030

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82270852Natural Science Foundation of Shanghai (Natural Science Foundation of Shanghai Municipality) 21ZR1450500Shanghai Minhang Science and Technology Commission (Science and Technology Commission, Shanghai Minhang) 2021MHZ028
6 · The paper itself

Abstract

backgroundThis study aimed to assess whether the Haptoglobin (Hp) genotype influences the relationship between hemoglobin (Hb) levels and the development of gestational diabetes mellitus (GDM). Additionally, it sought to evaluate the interaction and joint association of Hb levels and Hp genotype with GDM risk.

methodsThis retrospective study involved 358 women with GDM and 1324 women with normal glucose tolerance (NGT). Peripheral blood leukocytes were collected from 360 individuals at 14-16 weeks' gestation for Hp genotyping. GDM was diagnosed between 24-28 weeks' gestation. Interactive moderating effect, joint analysis, and mediation analysis were performed to evaluate the crosslink of Hb levels and Hp genotype with GDM risk.

resultsWomen who developed GDM had significantly higher Hb levels throughout pregnancy compared to those with NGT. Increase first-trimester Hb concentration was associated with a progressive rise in GDM incidence, glucose levels, glycosylated hemoglobin levels, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) values, cesarean delivery rates, and composite neonatal outcomes. Spline regression showed a significant linear association of GDM incidence with continuous first-trimester Hb level when the latter exceeded 122 g/L. Increased first-trimester Hb concentration was an independent risk factor for GDM development after adjusting for potential confounding factors in both the overall population and a matched case-control group. The Hp2-2 genotype was more prevalent among pregnant women with GDM when first-trimester Hb exceeded 122 g/L. Significant multiplicative and additive interactions were identified between Hb levels and Hp genotype for GDM risk, adjusted for age and pre-pregnancy BMI. The odds ratio (OR) for GDM development increased incrementally when stratified by Hb levels and Hp genotype. Moreover, first-trimester Hb level partially mediated the association between Hp genotype and GDM risk.

conclusionIncreased first-trimester Hb levels were closely associated with the development of GDM and adverse pregnancy outcomes, with this association moderated by the Hp2-2 genotype.

Indexed as

Diabetes, GestationalGenotypeHaptoglobinsHemoglobinsPregnancy Trimester, FirstAdultBlood GlucoseChinaEast Asian PeopleFemaleGlycated HemoglobinHumansInsulin ResistancePregnancyRetrospective StudiesRisk FactorsBlood GlucoseGlycated HemoglobinHaptoglobinsHemoglobins

Identifiers

PMID38951151
PMCPMC11217379

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.