Evidence map›Paper›PMID 38951147›Full record

ArticleCommunications biology2024

An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice.

Shuto Tanaka, Masataka Kawakita, Hikaru Yasui, Koichi Sudo, Fumie Itoh, Masato Sasaki, Nobuyuki Shibata, Hiromitsu Hara, Yoichiro Iwakura, Tomomi Hashidate-Yoshida and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shuto Tanaka *Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.ORCID 0009-0005-5520-6027
Masataka Kawakita *Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Hikaru YasuiDepartment of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Koichi SudoDepartment of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.ORCID 0000-0003-4102-3850
Fumie ItohDivision of Infection and Host Defense, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Masato SasakiDivision of Infection and Host Defense, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Nobuyuki ShibataDivision of Infection and Host Defense, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Hiromitsu HaraDepartment of Immunology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.ORCID 0000-0001-5429-2967
Yoichiro IwakuraResearch Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan.ORCID 0000-0002-9934-5775
Tomomi Hashidate-YoshidaDepartment of Lipid Life Science, National Center for Global Health and Medicine, Tokyo, Japan.
Hideo ShindouDepartment of Lipid Life Science, National Center for Global Health and Medicine, Tokyo, Japan.
Takao ShimizuDepartment of Lipid Signaling, National Center for Global Health and Medicine, Tokyo, Japan.
Taiki OyamaDepartment of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.ORCID 0000-0002-6822-4137
Himawari MatsunagaDepartment of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Kazuhiko TakaharaDepartment of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan. ktakahar@zoo.zool.kyoto-u.ac.jp.ORCID 0000-0003-4730-8187

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute immune responses with excess production of cytokines, lipid/chemical mediators, or coagulation factors, often result in lethal damage. In addition, the innate immune system utilizes multiple types of receptors that recognize neurotransmitters as well as pathogen-associated molecular patterns, making immune responses complex and clinically unpredictable. We here report an innate immune and adrenergic link inducing lethal levels of platelet-activating factor. Injecting mice with toll-like receptor (TLR) 4 ligand lipopolysaccharide (LPS), cell wall N-glycans of Candida albicans, and the α

Indexed as

Platelet Activating Factor1-Acylglycerophosphocholine O-AcyltransferaseAdrenergic alpha-2 Receptor AgonistsAnimalsCandida albicansImmunity, InnateLipopolysaccharidesMaleMiceMice, Inbred C57BLMice, KnockoutToll-Like Receptor 41-Acylglycerophosphocholine O-AcyltransferaseAdrenergic alpha-2 Receptor AgonistsLipopolysaccharidesPlatelet Activating FactorToll-Like Receptor 4

Identifiers

PMID38951147
PMCPMC11217416

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.