Evidence map›Paper›PMID 38951035›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Role of the Locus Coeruleus Arousal Promoting Neurons in Maintaining Brain Criticality across the Sleep-Wake Cycle.

Chengyu Huo, Fabrizio Lombardi, Carlos Blanco-Centurion, Priyattam J Shiromani, Plamen Ch Ivanov

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Searching for sleep in all the right places: My career in sleep research.Sleep advances : a journal of the Sleep Research Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chengyu HuoKeck Laboratory for Network Physiology, Department of Physics, Boston University, Boston, Massachusetts 02215.
Fabrizio LombardiKeck Laboratory for Network Physiology, Department of Physics, Boston University, Boston, Massachusetts 02215 plamen@buphy.bu.edu fabrizio.lombardi@unipd.it.ORCID 0000-0003-2623-5249
Carlos Blanco-CenturionDepartments of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425.
Priyattam J ShiromaniDepartments of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425.ORCID 0000-0002-2049-2802
Plamen Ch IvanovKeck Laboratory for Network Physiology, Department of Physics, Boston University, Boston, Massachusetts 02215 plamen@buphy.bu.edu fabrizio.lombardi@unipd.it.ORCID 0000-0001-7629-762X

Funding

Self Organized Criticality as a new paradigm of sleep regulationR01HL098437 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI IVANOV, PLAMEN CHRISTOV · 2011 to 2015
$2.3M
Hypothalamic Neuronal Activity During Insomnia Induced by Chronic Ethanol ExposureR01AA029129 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Carlos A. Blanco-Centurion · 2022 to 2026
$2.2M
Neuronal Activity in Sleep & Wake in Alzheimer's Disease MiceR21AG083236 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SHIROMANI, PRIYATTAM J. · 2023 to 2024
$347k
BLRD VA I01 BX000798NHLBI NIH HHS R01 HL098437NIAAA NIH HHS R01 AA029129NIA NIH HHS R21 AG083236
6 · The paper itself

Abstract

Sleep control depends on a delicate interplay among brain regions. This generates a complex temporal architecture with numerous sleep-stage transitions and intermittent fluctuations to micro-states and brief arousals. These temporal dynamics exhibit hallmarks of criticality, suggesting that tuning to criticality is essential for spontaneous sleep-stage and arousal transitions. However, how the brain maintains criticality remains not understood. Here, we investigate

Indexed as

ArousalLocus CoeruleusNeuronsRats, Sprague-DawleySleepWakefulnessAnimalsBrainDelta RhythmElectroencephalographyMaleRatsTheta Rhythmbrain rhythmscriticalitylocus coeruleusneural networkspower-lawsleep

Identifiers

PMID38951035
PMCPMC11358608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.