Evidence map›Paper›PMID 38950944›Full record

SynthesisThe British journal of general practice : the journal of the Royal College of General Practitioners2025

Preconception indicators and associations with health outcomes reported in UK routine primary care data: a systematic review.

Danielle Schoenaker, Elizabeth M Lovegrove, Emma H Cassinelli, Jennifer Hall, Majel McGranahan, Laura McGowan, Helen Carr, Nisreen A Alwan, Judith Stephenson, Keith M Godfrey

Abstract readSystematic Review
In one paragraph

Synthesis in The British journal of general practice : the journal of the Royal College of General Practitioners, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Preconception indicators and associations with health outcomes reported in UK routine primary care data: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025
    Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Danielle SchoenakerSchool of Human Development and Health, MRC Lifecourse Epidemiology Centre, University of Southampton; National Institute for Health and Care Research (NIHR) Southampton Biomedical Research Centre, University of Southampton; University Hospital Southampton NHS Foundation Trust, Southampton.ORCID 0000-0002-7652-990X
Elizabeth M LovegrovePrimary Care Research Centre, University of Southampton, Southampton.ORCID 0000-0003-0393-4266
Emma H CassinelliCentre for Public Health, Queen's University Belfast, Belfast.
Jennifer HallUniversity College London Elizabeth Garrett Anderson Institute for Women's Health, University College London, London.ORCID 0000-0002-2084-9568
Majel McGranahanWarwick Medical School, University of Warwick, Coventry.
Laura McGowanCentre for Public Health, Queen's University Belfast, Belfast.
Helen CarrNHS Surrey Heartlands Integrated Care Partnership, Guildford, Surrey.
Nisreen A AlwanSchool of Primary Care, Population Sciences and Medical Education, University of Southampton; NIHR Southampton Biomedical Research Centre, University of Southampton; University Hospital Southampton NHS Foundation Trust; NIHR Applied Research Collaboration Wessex, Southampton.
Judith StephensonUniversity College London Elizabeth Garrett Anderson Institute for Women's Health, University College London, London.
Keith M GodfreySchool of Human Development and Health, MRC Lifecourse Epidemiology Centre, University of Southampton; National Institute for Health and Care Research (NIHR) Southampton Biomedical Research Centre, University of Southampton; University Hospital Southampton NHS Foundation Trust, Southampton.

Funding

Medical Research Council MR/W01498X/1
6 · The paper itself

Abstract

backgroundRoutine primary care data may be a valuable resource for preconception health research and to inform the provision of preconception care.

aimTo review how primary care data could provide information on the prevalence of preconception indicators and examine associations with maternal and offspring health outcomes. DESIGN AND

settingSystematic review of observational studies using UK routine primary care data.

methodLiterature searches were conducted in March 2023 using five databases to identify observational studies that used national primary care data from individuals aged 15-49 years. Preconception indicators were defined as medical, behavioural, and social factors that may impact future pregnancies; health outcomes included those that may occur during and after pregnancy.

resultsFrom 5259 screened records, 42 articles were included. The prevalence of 37 preconception indicator measures was described for female patients, ranging from 0.01% for sickle cell disease to >20% for each of advanced maternal age, previous caesarean section (among those with a recorded pregnancy), overweight, obesity, smoking, depression, and anxiety (irrespective of pregnancy). Few studies reported indicators for male patients (

conclusionThe findings demonstrated that routinely collected UK primary care data could be used to identify patients' preconception care needs. Linking primary care data with health outcomes collected in other datasets is underutilised, but could help to quantify how optimising preconception health and care could reduce adverse outcomes for mothers and children.

Indexed as

Preconception CarePrimary Health CareAdolescentAdultFemaleHumansMalePregnancyPregnancy OutcomeUnited Kingdomgeneral practicepreconception carepregnancypregnancy outcomespre-pregnancy careprimary care

Identifiers

PMID38950944
PMCPMC11755573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.