ArticleRegional anesthesia and pain medicine2025
Cannabis use and acute postoperative pain outcomes in older adults: a propensity matched retrospective cohort study.
Article in Regional anesthesia and pain medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Drug-laced vaping-implications and emerging perioperative challenges for the anesthesiologist: a narrative review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Review
- Cannabis Use in Orthopaedic Surgery: Effects on Fracture Healing, Opioid Requirements, and Clinical Outcomes.Cureus · 2026Review
- Interpreting cannabis use and postoperative pain in older adults: methodologic considerations.Regional anesthesia and pain medicine · 2025Article
- Review of cannabis use and propofol anesthesia: recent insights and clinical implications.Current opinion in anaesthesiology · 2025Review
- Associations of cannabis on postoperative pain, length of stay and costs following mitral valve surgery.Journal of anesthesia, analgesia and critical care · 2025Article
- CORR Insights®: Do Medical and Recreational Marijuana State Laws Impact Trends in Postoperative Opioid Prescriptions Among Patients Who Have Undergone TJA?Clinical orthopaedics and related research · 2025Article
- Cannabis Use Documentation within the Electronic Health Record: A Use Case for Natural Language Processing Methods.Medical cannabis and cannabinoidsArticle
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Authors and funding
16 authors.
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Abstract
introductionCannabis use is increasing among older adults, but its impact on postoperative pain outcomes remains unclear in this population. We examined the association between cannabis use and postoperative pain levels and opioid doses within 24 hours of surgery.
methodsWe conducted a propensity score-matched retrospective cohort study using electronic health records data of 22 476 older surgical patients with at least 24-hour hospital stays at University of Florida Health between 2018 and 2020. Of the original cohort, 2577 patients were eligible for propensity-score matching (1:3 cannabis user: non-user). Cannabis use status was determined via natural language processing of clinical notes within 60 days of surgery and structured data. The primary outcomes were average Defense and Veterans Pain Rating Scale (DVPRS) score and total oral morphine equivalents (OME) within 24 hours of surgery.
results504 patients were included (126 cannabis users and 378 non-users). The median (IQR) age was 69 (65-72) years; 295 (58.53%) were male, and 442 (87.70%) were non-Hispanic white. Baseline characteristics were well balanced. Cannabis users had significantly higher average DVPRS scores (median (IQR): 4.68 (2.71-5.96) vs 3.88 (2.33, 5.17); difference=0.80; 95% confidence limit (CL), 0.19 to 1.36; p=0.01) and total OME (median (IQR): 42.50 (15.00-60.00) mg vs 30.00 (7.50-60.00) mg; difference=12.5 mg; 95% CL, 3.80 mg to 21.20 mg; p=0.02) than non-users within 24 hours of surgery. DISCUSSION: This study showed that cannabis use in older adults was associated with increased postoperative pain levels and opioid doses.
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