Evidence map›Paper›PMID 38950493›Full record

ArticleBiochemical and biophysical research communications2024

Nitric oxide contributes to rapid sclerostin protein loss following mechanical load.

Heather V Buck, Olivia M Torre, Jenna M Leser, Nicole R Gould, Christopher W Ward, Joseph P Stains

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Heather V BuckDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: hbuck@som.umaryland.edu.
Olivia M TorreDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: otorre@som.umaryland.edu.
Jenna M LeserDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: jleser@som.umaryland.edu.
Nicole R GouldDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: gouldn@wustl.edu.
Christopher W WardDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: ward@som.umaryland.edu.
Joseph P StainsDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: jstains@som.umaryland.edu.

Funding

Translational Imaging and Phenotyping CoreP30AR075042 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI MARY L BOUXSEIN, PAOLA DIVIETI PAJEVIC · 2019 to 2026
$7.4M
TRAINING PROGRAM IN INTEGRATIVE MEMBRANE BIOLOGYT32GM008181 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI RIZZO, MEGAN A, TRUDEAU, MATTHEW C · 1987 to 2022
$4.9M
Osteocyte CaMKII as a Critical Regulator of Bone Physiology and AnabolismR01AR071614 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Joseph P. Stains · 2018 to 2026
$2.6M
NIAMS NIH HHS P30 AR075042NIAMS NIH HHS R01 AR071614NIGMS NIH HHS T32 GM008181
6 · The paper itself

Abstract

In response to mechanical loading of bone, osteocytes produce nitric oxide (NO•) and decrease sclerostin protein expression, leading to an increase in bone mass. However, it is unclear whether NO• production and sclerostin protein loss are mechanistically linked, and, if so, the nature of their hierarchical relationship within an established mechano-transduction pathway. Prior work showed that following fluid-shear stress (FSS), osteocytes produce NOX2-derived reactive oxygen species, inducing calcium (Ca

Indexed as

Adaptor Proteins, Signal TransducingNitric OxideOsteocytesAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cell LineMechanotransduction, CellularMiceMice, Inbred C57BLStress, MechanicalAdaptor Proteins, Signal TransducingCalcium-Calmodulin-Dependent Protein Kinase Type 2Nitric OxideSost protein, mouseCaMKIIMechanical loadingNitric oxide synthaseNOSOsteocyteSclerostin

Identifiers

PMID38950493
PMCPMC12784413

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.