Evidence map›Paper›PMID 38950369›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Activity of DNA polymerase κ across the genome in human fibroblasts.

Mariela C Torres, Abbey Rebok, Dongxiao Sun, Thomas E Spratt

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mariela C TorresDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, Hershey, PA 17033.ORCID 0000-0002-1988-6898
Abbey RebokDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, Hershey, PA 17033.ORCID 0000-0003-1665-4538
Dongxiao SunDepartment of Pharmacology, Pennsylvania State University, Hershey, PA 17033.ORCID 0000-0003-4902-4292
Thomas E SprattDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, Hershey, PA 17033.ORCID 0000-0002-6805-3729

Funding

Genotoxicity and Repair of Tobacco-Specific Nitrosamine DNA AdductsR01ES021762 · NIEHS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SPRATT, THOMAS E · 2012 to 2022
$3.7M
HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) 5R01ES021762-10NIEHS NIH HHS R01 ES021762
6 · The paper itself

Abstract

DNA polymerase κ (Polκ) is a specialized polymerase that has multiple cellular roles such as translesion DNA synthesis, replication of repetitive sequences, and nucleotide excision repair. We have developed a method for capturing DNA synthesized by Polκ utilizing a Polκ-specific substrate,

Indexed as

DNA-Directed DNA PolymeraseFibroblastsGenome, HumanCell LineDNADNA RepairDNA ReplicationHumansY-Family DNA PolymerasesDNADNA-Directed DNA PolymerasePOLK protein, humanY-Family DNA PolymerasesDNADNA polymerase kappaDNA replication

Identifiers

PMID38950369
PMCPMC11252913

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.