Evidence map›Paper›PMID 38950361›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

DNA polymerase κ participates in early S-phase DNA replication in human cells.

Feng Tang, Yinan Wang, Ting Zhao, Jun Yuan, Andrew H Kellum, Yinsheng Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Feng Tang *Department of Chemistry, University of California Riverside, Riverside, CA 92521-0403.ORCID 0000-0001-9748-3712
Yinan Wang *Department of Chemistry, University of California Riverside, Riverside, CA 92521-0403.
Ting ZhaoEnvironmental Toxicology Graduate Program, University of California Riverside, Riverside, CA 92521-0403.
Jun YuanDepartment of Chemistry, University of California Riverside, Riverside, CA 92521-0403.
Andrew H KellumDepartment of Chemistry, University of California Riverside, Riverside, CA 92521-0403.
Yinsheng WangDepartment of Chemistry, University of California Riverside, Riverside, CA 92521-0403.

Funding

Chemical Biology of DNA and RNA AlkylationR35ES031707 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Yinsheng Wang · 2020 to 2026
$6.1M
Research Training in Environmental ToxicologyT32ES018827 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Yinsheng Wang · 2010 to 2026
$5.3M
DNA-Protein Cross-Linking Sequencing for Genome-Wide Mapping of Abasic Sites at Single-Nucleotide ResolutionR00ES035446 · NIEHS · UNIVERSITY OF FLORIDA · PI Feng Tang · 2025 to 2026
$492k
DNA–Protein Cross-Linking Sequencing for Genome-Wide Mapping of Abasic Sites at Single-Nucleotide ResolutionK99ES035446 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI TANG, FENG · 2023 to 2023
$119k
NIEHS NIH HHS K99 ES035446NIEHS NIH HHS R00 ES035446NIEHS NIH HHS R35 ES031707NIEHS NIH HHS T32 ES018827
6 · The paper itself

Abstract

Cycling cells replicate their DNA during the S phase through a defined temporal program known as replication timing. Mutation frequencies, epigenetic chromatin states, and transcriptional activities are different for genomic regions that are replicated early and late in the S phase. Here, we found from ChIP-Seq analysis that DNA polymerase (Pol) κ is enriched in early-replicating genomic regions in HEK293T cells. In addition, by feeding cells with

Indexed as

DNA-Directed DNA PolymeraseDNA ReplicationS PhaseDNA Replication TimingGenome, HumanHEK293 CellsHumansY-Family DNA PolymerasesDNA-Directed DNA PolymerasePOLK protein, humanY-Family DNA PolymerasesDNA replicationmutagenesisreplication timingtranslesion synthesis polymerase

Identifiers

PMID38950361
PMCPMC11252992

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.