ArticleOptics letters2024
Axially swept open-top light-sheet microscopy for densely labeled clinical specimens.
Article in Optics letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Deep-learning triage of three-dimensional pathology datasets for comprehensive and efficient pathologist assessments.Nature biomedical engineering · 2026Article
- Prototype-based AI triage for 3D pathology.bioRxiv : the preprint server for biology · 2026Article
- 3D pathology-guided microdissection.Nature methods · 2026Article
- High content 3D imaging by dual-view oblique plane microscopy.PNAS nexus · 2025Article
- 3D pathology-guided microdissection.bioRxiv : the preprint server for biology · 2025Article
- Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue.Nature biotechnology · 2025Article
- Mesoscopic axially swept oblique plane microscope for the imaging of freely moving organisms with near-isotropic resolution.Biomedical optics express · 2024Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Open-top light-sheet (OTLS) microscopy offers rapid 3D imaging of large optically cleared specimens. This enables nondestructive 3D pathology, which provides key advantages over conventional slide-based histology including comprehensive sampling without tissue sectioning/destruction and visualization of diagnostically important 3D structures. With 3D pathology, clinical specimens are often labeled with small-molecule stains that broadly target nucleic acids and proteins, mimicking conventional hematoxylin and eosin (H&E) dyes. Tight optical sectioning helps to minimize out-of-focus fluorescence for high-contrast imaging in these densely labeled tissues but has been challenging to achieve in OTLS systems due to trade-offs between optical sectioning and field of view. Here we present an OTLS microscope with voice-coil-based axial sweeping to circumvent this trade-off, achieving 2 µm axial resolution over a 750 × 375 µm field of view. We implement our design in a non-orthogonal dual-objective (NODO) architecture, which enables a 10-mm working distance with minimal sensitivity to refractive index mismatches, for high-contrast 3D imaging of clinical specimens.
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Registered trials
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