Evidence map›Paper›PMID 38950092›Full record

Trial reportOncology nursing forum2024

DNA Methylation of BDNF and RASA2 Genes Is Associated With Cognitive Function in Postmenopausal Women With Breast Cancer.

Myeong-Ga Cho, Susan M Sereika, Meredith H Cummings, Kirk I Erickson, Catherine M Bender, Yvette P Conley

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Oncology nursing forum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Myeong-Ga ChoUniversity of Pittsburgh.
Susan M SereikaAssociate professors School of Nursing, University of Pittsburgh, Pennsylvania.
Meredith H CummingsUniversity of Pittsburgh.
Kirk I EricksonAdventHealth Research Institute.
Catherine M BenderUniversity of Pittsburgh.
Yvette P ConleyUniversity of Pittsburgh.

Funding

Targeting Research and Academic Training of Nurses in GenomicsT32NR009759 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONLEY, YVETTE P · 2006 to 2025
$4.5M
Influence of Exercise on Neurocognitive Function in Breast CancerR01CA196762 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENDER, CATHERINE M., ERICKSON, KIRK I · 2016 to 2020
$3.0M
Epigenomics of Neurocognitive Function in Breast CancerR01CA221882 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENDER, CATHERINE M., CONLEY, YVETTE P · 2018 to 2022
$2.2M
NCI NIH HHS R01 CA196762NCI NIH HHS R01 CA221882NINR NIH HHS T32 NR009759
6 · The paper itself

Abstract

objectivesTo determine associations among DNA methylation of brain-derived neurotrophic factor (BDNF) and RAS p21 protein activator 2 (RASA2) genes with processing speed and perceived cognitive function. SAMPLE &

settingThis was a cross-sectional, secondary analysis of baseline data from a randomized controlled trial, the Exercise Program in Cancer and Cognition Study. METHODS & VARIABLES: Data included M values for DNA methylation of the BDNF and RASA2 genes; processing speed, objectively measured using the Grooved Pegboard and Digit Vigilance Test scores; and perceived cognitive function, self-reported using the Patient Assessment of Own Functioning Inventory. Regression analysis was conducted.

resultsGreater methylation of cg21291635 of the BDNF gene (p = 0.01) and cg20247102 of the RASA2 gene (p = 0.013) were associated with poorer processing speed, whereas greater methylation of cg20108357 of the BDNF gene (p < 0.001) and cg00567892 of the RASA2 gene (p = 0.019) were associated with better perceived cognitive function. IMPLICATIONS FOR NURSING: Gene methylation variations were demonstrated, suggesting the genes' potential roles and two possible distinct mechanisms of cognitive function in cancer.

Indexed as

Brain-Derived Neurotrophic FactorBreast NeoplasmsCognitionDNA MethylationPostmenopauseAgedCross-Sectional StudiesFemaleHumansMiddle AgedBDNF protein, humanBrain-Derived Neurotrophic Factorbreast cancercognitionDNA methylationperceived cognitive functionprocessing speed

Identifiers

PMID38950092
PMCPMC12011312

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.