Evidence map›Paper›PMID 38949858›Full record

ArticleFuture medicinal chemistry2024

A novel chromone-based as a potential inhibitor of ULK1 that modulates autophagy and induces apoptosis in colon cancer.

Nur Farisya Shamsudin, Sze-Wei Leong, Andreas Koeberle, Utid Suriya, Thanyada Rungrotmongkol, Suet Lin Chia, Muhammad Taher, Muhammad Salahuddin Haris, Hussah Abdullah Alshwyeh, Areej A Alosaimi and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nur Farisya ShamsudinDrug Discovery & Synthetic Chemistry Research Group, Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Bandar Indera Mahkota, Kuantan 25200, Pahang, Malaysia.
Sze-Wei LeongDepartment of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia.
Andreas KoeberleMichael Popp Institute & Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck 6020, Austria.
Utid SuriyaStructural & Computational Biology Research Unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Thanyada RungrotmongkolStructural & Computational Biology Research Unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Suet Lin ChiaUPM - MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Muhammad TaherDepartment of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Kuantan 25200, Pahang, Malaysia.
Muhammad Salahuddin HarisDepartment of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Kuantan 25200, Pahang, Malaysia.
Hussah Abdullah AlshwyehBasic & Applied Scientific Research Centre, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Areej A AlosaimiDepartment of Biology, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Ahmed MedianiInstitute of Systems Biology, Universiti Kebangsaan Malaysia (UKM), Bangi 43600, Malaysia.
Muna Abdulsalam IlowefahDepartment of Food Technology, Faculty of Food Science, Wadi Alshatti University, Libya.
Deri IslamiFaculty of Pharmacy & Health Sciences, Universitas Abdurrab, Jalan Riau Ujung, Pekanbaru 28292, Riau, Indonesia.
Siti Munirah Mohd FaudziLaboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia.
Mohd Fadhlizil Fasihi Mohd AluwiFaculty of Industrial Sciences & Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, Gambang 26300, Pahang, Malaysia.
Lam Kok WaiDrugs & Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.
Kamal RullahDrug Discovery & Synthetic Chemistry Research Group, Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Bandar Indera Mahkota, Kuantan 25200, Pahang, Malaysia.ORCID 0000-0001-6856-9373

Funding

Ministry of Higher Education (MOHE) Malaysia Fundamental Research Grant Scheme (FRGS/1/2022/STG04/UIAM/02/2)
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsApoptosisAutophagyAutophagy-Related Protein-1 HomologChromonesColonic NeoplasmsMolecular Docking SimulationCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansIntracellular Signaling Peptides and ProteinsMolecular StructureProtein Kinase InhibitorsReactive Oxygen SpeciesStructure-Activity RelationshipAntineoplastic AgentsAutophagy-Related Protein-1 HomologChromonesIntracellular Signaling Peptides and ProteinsProtein Kinase InhibitorsReactive Oxygen SpeciesULK1 protein, humanapoptosisautophagychromonecolon cancerULK1 inhibitor

Identifiers

PMID38949858
PMCPMC11370956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.