Evidence map›Paper›PMID 38948947›Full record

ArticleCNS neuroscience & therapeutics2024

Optic nerve compression associated with visual cortex functional alteration in dysthyroid optic neuropathy: A combined orbital and brain imaging study.

Haiyang Zhang, Yuting Liu, Mengda Jiang, Duojin Xia, Yuhang Peng, Ling Zhu, Xiaofeng Tao, Jue Wang, Jipeng Li, Jing Sun and 4 more

Abstract read
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In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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0cells of the map it votes in
5citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Haiyang ZhangDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuting LiuDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mengda JiangDepartment of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Duojin XiaSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Yuhang PengDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ling ZhuDepartment of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaofeng TaoDepartment of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jue WangInstitute of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.ORCID 0000-0003-4790-4827
Jipeng LiDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jing SunDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yinwei LiDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xuefei SongDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Huifang ZhouDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-8636-861X
Xianqun FanDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

Clinical Acceleration Program of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine JYLJ202202Cross disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine JYJC202115National Natural Science Foundation of China 81930024National Natural Science Foundation of China 82201235National Natural Science Foundation of China 82271122Science and Technology Commission of Shanghai Municipality 20DZ22708Science and Technology Commission of Shanghai Municipality 20DZ2270800Shanghai Key Clinical Specialty, Shanghai Eye Disease Research Center 2022ZZ01003
6 · The paper itself

Abstract

aimsTo investigate the alterations of the optic nerve and visual cortex in dysthyroid optic neuropathy (DON), a subgroup of thyroid eye disease (TED).

methodsMultiple orbital imaging biomarkers related to optic nerve compression and the amplitude of low-frequency fluctuations (ALFF) of the brain were obtained from 47 patients with DON, 56 TED patients without DON (nDON), and 37 healthy controls (HC). Correlation analyses and diagnostic tests were implemented.

resultsCompared with HC, the nDON group showed alterations in orbital imaging biomarkers related to optic nerve compression in posterior segments, as well as ALFF of the right inferior temporal gyrus and left fusiform gyrus. DON differed from nDON group mainly in the modified muscle index of the posterior segment of optic nerve, and ALFF of orbital part of right superior frontal gyrus, right hippocampus, and right superior temporal gyrus. Orbital and brain imaging biomarkers were significantly correlated with each other. Diagnostic models attained an area under a curve of 0.80 for the detection of DON.

conclusionThe combined orbital and brain imaging study revealed alterations of the visual pathway in patients with TED and DON as well as provided diagnostic value. The initiation of alterations in the visual cortex in TED may precede the onset of DON.

Indexed as

Graves OphthalmopathyMagnetic Resonance ImagingOptic Nerve DiseasesVisual CortexAdultAgedFemaleHumansMaleMiddle AgedOptic NerveOrbitdysthyroid optic neuropathyfunctional magnetic resonance imagingoptic nervevision disordersvisual cortex

Identifiers

PMID38948947
PMCPMC11215484

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