Evidence map›Paper›PMID 38948875›Full record

ArticlebioRxiv : the preprint server for biology2024

Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function.

Gabriel B Loeb, Pooja Kathail, Richard Shuai, Ryan Chung, Reinier J Grona, Sailaja Peddada, Volkan Sevim, Scot Federman, Karl Mader, Audrey Chu and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Gabriel B LoebDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-8514-8180
Pooja KathailDepartment of Electrical Engineering and Computer Science, Center for Computational Biology, University of California Berkeley, Berkeley, CA, USA.
Richard ShuaiDepartment of Electrical Engineering and Computer Science, Center for Computational Biology, University of California Berkeley, Berkeley, CA, USA.
Ryan ChungDepartment of Electrical Engineering and Computer Science, Center for Computational Biology, University of California Berkeley, Berkeley, CA, USA.
Reinier J GronaDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Sailaja PeddadaLaboratory for Genomics Research, University of California, San Francisco, San Francisco, CA, USA.
Volkan SevimLaboratory for Genomics Research, University of California, San Francisco, San Francisco, CA, USA.
Scot FedermanLaboratory for Genomics Research, University of California, San Francisco, San Francisco, CA, USA.
Karl MaderLaboratory for Genomics Research, University of California, San Francisco, San Francisco, CA, USA.
Audrey ChuGenomic Sciences, GlaxoSmithKline, San Francisco, CA, USA.
Jonathan DavitteGenomic Sciences, GlaxoSmithKline, San Francisco, CA, USA.
Juan DuDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Alexander R GuptaDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Chun Jimmie YeDivision of Rheumatology, Department of Medicine; Bakar Computational Health Sciences Institute; Parker Institute for Cancer Immunotherapy; Institute for Human Genetics; Department of Epidemiology & Biostatistics; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA and Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.ORCID 0000-0001-6560-3783
Shawn ShaferLaboratory for Genomics Research, University of California, San Francisco, San Francisco, CA, USA.
Laralynne PrzybylaLaboratory for Genomics Research, University of California, San Francisco, San Francisco, CA, USA.
Radu RapiteanuGenomic Sciences, GlaxoSmithKline, San Francisco, CA, USA.
Nilah IoannidisDepartment of Electrical Engineering and Computer Science, Center for Computational Biology, University of California Berkeley, Berkeley, CA, USA.
Jeremy F ReiterCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, US.ORCID 0000-0002-6512-320X

Funding

Hedgehog signaling at the cell's antenna: Smoothened and the primary ciliumR01AR054396 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeremy F Reiter · 2007 to 2026
$9.0M
Filling a Void of Research (FAVOR) Training for Transplant SurgeonsT32AI125222 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PETER G STOCK, Minnie M Sarwal · 2016 to 2026
$3.4M
Understanding Ciliary Functions in Mammalian DevelopmentR01HD089918 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REITER, JEREMY F, YODER, BRADLEY K. · 2017 to 2021
$3.0M
NIAID NIH HHS T32 AI125222NIAMS NIH HHS R01 AR054396NICHD NIH HHS R01 HD089918
6 · The paper itself

Abstract

Kidney disease is highly heritable; however, the causal genetic variants, the cell types in which these variants function, and the molecular mechanisms underlying kidney disease remain largely unknown. To identify genetic loci affecting kidney function, we performed a GWAS using multiple kidney function biomarkers and identified 462 loci. To begin to investigate how these loci affect kidney function, we generated single-cell chromatin accessibility (scATAC-seq) maps of the human kidney and identified candidate

Identifiers

PMID38948875
PMCPMC11212968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.