Evidence map›Paper›PMID 38948871›Full record

ArticlebioRxiv : the preprint server for biology2024

Noradrenergic tuning of arousal is coupled to coordinated movements.

Li Li, Akshay N Rana, Esther M Li, Myesa O Travis, Michael R Bruchas

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Li LiDepartments of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA.
Akshay N RanaDepartments of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA.
Esther M LiDepartments of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA.
Myesa O TravisSeattle Children's Research Institute" Seattle, WA 98101, USA.
Michael R BruchasDepartments of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA.

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI LARRY S ZWEIFEL · 2019 to 2026
$13.0M
Decoding Locus Coeruleus Neural Circuits and Signaling In Negative AffectR01MH112355 · NIMH · WASHINGTON UNIVERSITY · PI Michael R. Bruchas · 2016 to 2026
$5.3M
Unraveling the Locus Coeruleus Circuitry in Opioidinduced Sleep DisturbancesR00DA053336 · NIDA · SEATTLE CHILDREN'S HOSPITAL · PI LI, LI · 2023 to 2025
$747k
Unraveling the Locus Coeruleus Circuitry in Opioidinduced Sleep DisturbancesK99DA053336 · NIDA · UNIVERSITY OF WASHINGTON · PI LI, LI · 2021 to 2022
$350k
NIDA NIH HHS K99 DA053336NIDA NIH HHS P30 DA048736NIDA NIH HHS R00 DA053336NIMH NIH HHS R01 MH112355
6 · The paper itself

Abstract

Matching arousal level to the motor activity of an animal is important for efficiently allocating cognitive resources and metabolic supply in response to behavioral demands, but how the brain coordinates changes in arousal and wakefulness in response to motor activity remains an unclear phenomenon. We hypothesized that the locus coeruleus (LC), as the primary source of cortical norepinephrine (NE) and promoter of cortical and sympathetic arousal, is well-positioned to mediate movement-arousal coupling. Here, using a combination of physiological recordings, fiber photometry, optogenetics, and behavioral tracking, we show that the LC

Indexed as

anesthetic emergencearousalLocus coeruleusmovementsympathetic activation

Identifiers

PMID38948871
PMCPMC11212988

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.