Evidence map›Paper›PMID 38948860›Full record

ArticlebioRxiv : the preprint server for biology2024

Hair follicle-resident progenitor cells are a major cellular contributor to heterotopic subcutaneous ossifications in a mouse model of Albright hereditary osteodystrophy.

Patrick McMullan, Peter Maye, Sierra H Root, Qingfen Yang, Sarah Edie, David Rowe, Ivo Kalajzic, Emily L Germain-Lee

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Patrick McMullanDepartment of Pediatrics, University of Connecticut School of Medicine, Farmington, CT.ORCID 0000-0002-7952-5322
Peter MayeDepartment of Reconstructive Sciences, Center for Regenerative Medicine and Skeletal Development, University of Connecticut School of Dental Medicine, Farmington, CT.
Sierra H RootDepartment of Reconstructive Sciences, Center for Regenerative Medicine and Skeletal Development, University of Connecticut School of Dental Medicine, Farmington, CT.
Qingfen YangDepartment of Pediatrics, University of Connecticut School of Medicine, Farmington, CT.
Sarah EdieThe Jackson Laboratory, Farmington, CT.
David RoweDepartment of Reconstructive Sciences, Center for Regenerative Medicine and Skeletal Development, University of Connecticut School of Dental Medicine, Farmington, CT.
Ivo KalajzicDepartment of Reconstructive Sciences, Center for Regenerative Medicine and Skeletal Development, University of Connecticut School of Dental Medicine, Farmington, CT.
Emily L Germain-LeeDepartment of Pediatrics, University of Connecticut School of Medicine, Farmington, CT.ORCID 0000-0002-5727-610X

Funding

ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI MARSH, LAURA · 1985 to 2007
$37.3M
Skeletal, Craniofacial and Oral Biology Training GrantT90DE021989 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MINA, MINA · 2011 to 2022
$4.5M
Extracellular regulation of bone mass by transforming growth factor-ß-related ligands and their binding proteinsR01AR081659 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI EMILY L GERMAIN-LEE, Se-Jin Lee · 2022 to 2026
$3.1M
The role of G protein-coupled signaling in neurocognitive and psychosocialabnormalitiesR21HD078864 · NICHD · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GERMAIN-LEE, EMILY L · 2016 to 2017
$451k
NCRR NIH HHS M01 RR000052NIAMS NIH HHS R01 AR081659NICHD NIH HHS R21 HD078864NIDCR NIH HHS T90 DE021989
6 · The paper itself

Abstract

Heterotopic ossifications (HOs) are the pathologic process by which bone inappropriately forms outside of the skeletal system. Despite HOs being a persistent clinical problem in the general population, there are no definitive strategies for their prevention and treatment due to a limited understanding of the cellular and molecular mechanisms contributing to lesion development. One disease in which the development of heterotopic subcutaneous ossifications (SCOs) leads to morbidity is Albright hereditary osteodystrophy (AHO). AHO is caused by heterozygous inactivation of

Identifiers

PMID38948860
PMCPMC11213030

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.