Evidence map›Paper›PMID 38948813›Full record

ArticlebioRxiv : the preprint server for biology2024

Full-length direct RNA sequencing reveals extensive remodeling of RNA expression, processing and modification in aging

Erin C Schiksnis, Ian A Nicastro, Amy E Pasquinelli

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Erin C SchiksnisMolecular Biology Department, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093-0349, USA.ORCID 0000-0003-2756-8168
Ian A NicastroMolecular Biology Department, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093-0349, USA.ORCID 0000-0002-4058-4720
Amy E PasquinelliMolecular Biology Department, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093-0349, USA.ORCID 0000-0002-9511-0039

Funding

GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8M
Pathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9M
Biogenesis and Function of Regulatory RNAsR35GM127012 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AMY E. PASQUINELLI · 2018 to 2026
$3.6M
Role of miRNA Argonautes in organismal agingR01AG056562 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PASQUINELLI, AMY E. · 2017 to 2021
$1.9M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NIA NIH HHS R01 AG056562NIGMS NIH HHS R35 GM127012NIGMS NIH HHS T32 GM007240NIGMS NIH HHS T32 GM133351NIH HHS S10 OD026929
6 · The paper itself

Abstract

Organismal aging is marked by decline in cellular function and anatomy, ultimately resulting in death. To inform our understanding of the mechanisms underlying this degeneration, we performed standard RNA sequencing and Nanopore direct RNA sequencing over an adult time course in

Indexed as

agingC. eleganslong-read sequencingRNA modificationsRNA processing

Identifiers

PMID38948813
PMCPMC11213008

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.