Evidence map›Paper›PMID 38948796›Full record

ArticlebioRxiv : the preprint server for biology2024

Acute nicotine vapor normalizes sensorimotor gating and reduces locomotor activity deficits in HIV-1 transgenic rats.

Neal A Jha, Samantha M Ayoub, M Melissa Flesher, Kathleen Morton, Megan Sikkink, Giordano de Guglielmo, Jibran Y Khokhar, Arpi Minassian, Arthur L Brody, Jared W Young

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In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Neal A JhaDepartment of Psychiatry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0009-0001-2671-8040
Samantha M AyoubDepartment of Psychiatry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0009-0006-1846-3232
M Melissa FlesherDepartment of Psychiatry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093, USA.
Kathleen MortonDepartment of Psychiatry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093, USA.
Megan SikkinkDepartment of Psychiatry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093, USA.
Giordano de GuglielmoDepartment of Psychiatry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0002-4782-7430
Jibran Y KhokharDepartment of Anatomy and Cell Biology, University of Western Ontario 1151 Richmond Street, London, ON N61 3K7, Canada.ORCID 0000-0002-2169-2275
Arpi MinassianDepartment of Psychiatry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0001-5883-1147
Arthur L BrodyDepartment of Psychiatry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0003-2614-8495
Jared W YoungDepartment of Psychiatry, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093, USA.

Funding

Translational Studies of Cannabis Administration, Cognition, and the Endocannabinoid System in HIVR01DA051295 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MINASSIAN, ARPI, YOUNG, JARED WILLIAM · 2021 to 2025
$4.3M
NIDA NIH HHS R01 DA051295
6 · The paper itself

Abstract

Rationale: Despite improved life expectancy of people with HIV (PWH), HIV-associated neurocognitive impairment (NCI) persists, alongside deficits in sensorimotor gating and neuroinflammation. PWH exhibit high smoking rates, possibly due to neuroprotective, anti-inflammatory, and cognitive-enhancing effects of nicotine, suggesting potential self-medication. Objectives: Here, we tested the effects of acute nicotine vapor exposure on translatable measures of sensorimotor gating and exploratory behavior in the HIV-1 transgenic (HIV-1Tg) rat model of HIV. Methods: Male and female HIV-1Tg and F344 control rats (n=57) were exposed to acute nicotine or vehicle vapor. Sensorimotor gating was assessed using prepulse inhibition (PPI) of the acoustic startle response, and exploratory behavior was evaluated using the behavioral pattern monitor (BPM). Results: Vehicle-treated HIV-1Tg rats exhibited PPI deficits at low prepulse intensities compared to F344 controls, as seen previously. No PPI deficits were observed in nicotine-treated HIV1-Tg rats, however. HIV-1Tg rats were hypoactive in the BPM relative to controls, whilst nicotine vapor increased activity and exploratory behavior across genotypes. Cotinine analyses confirmed comparable levels of the primary metabolite of nicotine across genotypes. Conclusions: Previous findings of PPI deficits in HIV-1Tg rats were replicated and, importantly, attenuated by acute nicotine vapor. Evidence for similar cotinine levels suggest a nicotine-specific effect in HIV-1Tg rats. HIV-1Tg rats had reduced exploratory behavior compared to controls, attenuated by acute nicotine vapor. Therefore, acute nicotine may be beneficial for remediating sensorimotor and locomotor activity deficits in PWH. Future studies should determine the long-term effects of nicotine vapor on similar HIV/NCI-relevant behaviors.

Indexed as

e-CigarettesHIVHIV-associated neurocognitive disorderNicotinePPI

Identifiers

PMID38948796
PMCPMC11212989

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.