Evidence map›Paper›PMID 38948781›Full record

ArticlebioRxiv : the preprint server for biology2025

Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2.

Siyu Chen, Tamar Basiashvili, Joshua Hutchings, Marta Sanz Murillo, Amalia Villagran Suarez, Erica Xiong, Jaime Alegrio Louro, Andres E Leschziner, Elizabeth Villa

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Siyu ChenDepartment of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-4565-4772
Tamar BasiashviliDepartment of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-0394-3832
Joshua HutchingsDepartment of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-6841-8583
Marta Sanz MurilloAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.ORCID 0000-0002-6175-9315
Amalia Villagran SuarezAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.ORCID 0000-0003-3400-2330
Erica XiongAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.
Jaime Alegrio LouroAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.ORCID 0000-0002-2800-923X
Andres E LeschzinerDepartment of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-7732-7023
Elizabeth VillaDepartment of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-4677-9809

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
NIGMS NIH HHS R01 GM129325
6 · The paper itself

Abstract

Parkinson's Disease (PD) is the second most common neurodegenerative disorder. Mutations in leucine-rich repeat kinase 2 (LRRK2), a multi-domain protein containing both a kinase and a GTPase, are a leading cause of the familial form of PD. Pathogenic LRRK2 mutations increase LRRK2 kinase activity. While the bulk of LRRK2 is found in the cytosol, the protein associates with membranes where its Rab GTPase substrates are found, and under certain conditions, with microtubules. Integrative structural studies using single-particle cryo-electron microscopy (cryo-EM) and

Identifiers

PMID38948781
PMCPMC11212993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.