Evidence map›Paper›PMID 38948772›Full record

ArticlebioRxiv : the preprint server for biology2024

Acute microtubule changes linked to DMD pathology are insufficient to impair contractile function or enhance contraction-induced injury in healthy muscle.

Camilo Vanegas, Jeanine Ursitti, Jacob G Kallenbach, Kaylie Pinto, Anicca Harriot, Andrew K Coleman, Guoli Shi, Christopher W Ward

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Camilo VanegasDepartment of Orthopedics, University of Maryland School of Medicine, Baltimore, MD, USA.
Jeanine UrsittiDepartment of Orthopedics, University of Maryland School of Medicine, Baltimore, MD, USA.
Jacob G KallenbachDepartment of Orthopedics, University of Maryland School of Medicine, Baltimore, MD, USA.
Kaylie PintoDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.
Anicca HarriotDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.
Andrew K ColemanCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, USA.
Guoli ShiDepartment of Orthopedics, University of Maryland School of Medicine, Baltimore, MD, USA.
Christopher W WardDepartment of Orthopedics, University of Maryland School of Medicine, Baltimore, MD, USA.

Funding

Interdisciplinary Training Program Muscle BiologyT32AR007592 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Aikaterini Kontrogianni-Konstantopoulos · 1996 to 2026
$11.7M
Microtubule Regulated Mechanotransduction in Skeletal MuscleR01AR071618 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI WARD, CHRISTOPHER WILLIAM · 2017 to 2021
$2.6M
Osteocyte CaMKII as a Critical Regulator of Bone Physiology and AnabolismR01AR071614 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Joseph P. Stains · 2018 to 2026
$2.6M
Stretch Dependent Signaling in Dystrophic Skeletal MuscleR01AR062554 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI WARD, CHRISTOPHER WILLIAM · 2013 to 2014
$675k
NIAMS NIH HHS R01 AR062554NIAMS NIH HHS R01 AR071614NIAMS NIH HHS R01 AR071618NIAMS NIH HHS T32 AR007592
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is marked by the genetic deficiency of the dystrophin protein in striated muscle whose consequence is a cascade of cellular changes that predispose the susceptibility to contraction injury central to DMD pathology. Recent evidence identified the proliferation of microtubules enriched in post-translationally modified tubulin as a consequence of dystrophins absence that increases the passive mechanics of the muscle fiber and the excess mechanotransduction elicited reactive oxygen species and calcium signals that promote contraction injury. Motivated by evidence that acutely normalizing the disease microtubule alterations reduced contraction injury in murine DMD muscle (

Indexed as

Duchenne muscular dystrophyeccentric contractionEpothilone Dmechanotransductionmicrotubulesskeletal muscle

Identifiers

PMID38948772
PMCPMC11212994

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.