Evidence map›Paper›PMID 38948769›Full record

ArticlebioRxiv : the preprint server for biology2024

Chondroitin sulfate glycan sulfation patterns influence histochemical labeling of perineuronal nets: a comparative study of interregional distribution in human and mouse brain.

Claudia Belliveau, Stéphanie Théberge, Stefanie Netto, Reza Rahimian, Gohar Fakhfouri, Clémentine Hosdey, Maria Antonietta Davoli, Aarun Hendrickson, Kathryn Hao, Bruno Giros and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Claudia BelliveauMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Qc, Canada.ORCID 0000-0002-6027-3938
Stéphanie ThébergeMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Qc, Canada.
Stefanie NettoMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Qc, Canada.
Reza RahimianMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Qc, Canada.ORCID 0000-0002-3509-0400
Gohar FakhfouriDepartment of Psychiatry, McGill University, Montreal, Qc, Canada.ORCID 0000-0003-0829-2143
Clémentine HosdeyMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Qc, Canada.
Maria Antonietta DavoliMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Qc, Canada.ORCID 0009-0009-1846-7454
Aarun HendricksonDepartment of Medicinal Chemistry, University of Washington, Seattle, USA.
Kathryn HaoHealth and Human Sciences, University of Southern California, Los Angeles, USA.
Bruno GirosDepartment of Psychiatry, McGill University, Montreal, Qc, Canada.ORCID 0000-0001-5876-9822
Gustavo TureckiMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Qc, Canada.ORCID 0000-0003-4075-2736
Kimberly M AlongeDepartment of Medicinal Chemistry, University of Washington, Seattle, USA.ORCID 0000-0002-2171-1640
Naguib MechawarMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Qc, Canada.ORCID 0000-0003-4960-756X

Funding

University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0M
Maternal immune activation remodeling of offspring glycosaminoglycan sulfation patterns during neurodevelopmentDP2AI171150 · NIAID · UNIVERSITY OF WASHINGTON · PI Kimberly Michele Alonge · 2023 to 2026
$2.0M
MALDI imaging of glial scar-forming glycans in Alzheimers diseaseR21AG074152 · NIA · UNIVERSITY OF WASHINGTON · PI ALONGE, KIMBERLY MICHELE · 2021 to 2022
$485k
NIAID NIH HHS DP2 AI171150NIA NIH HHS P30 AG066509NIA NIH HHS R21 AG074152
6 · The paper itself

Abstract

Perineuronal nets (PNNs) are a condensed subtype of extracellular matrix that form a net-like coverings around certain neurons in the brain. PNNs are primarily composed of chondroitin sulfate (CS) proteoglycans from the lectican family that consist of CS-glycosaminoglycan (CS-GAG) side chains attached to a core protein. CS disaccharides can exist in various isoforms with different sulfation patterns. Literature suggests that CS disaccharide sulfation patterns can influence the function of PNNs as well as their labeling. This study was conducted to characterize such interregional CS disaccharide sulfation pattern differences in adult human (N = 81) and mouse (N = 19) brains. Liquid chromatography tandem mass spectrometry was used to quantify five different CS disaccharide sulfation patterns, which were then compared to immunolabeling of PNNs using

Indexed as

Adverse Childhood ExperiencesChondroitin sulfateExtracellular MatrixHumanMouse

Identifiers

PMID38948769
PMCPMC11212934

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.