Evidence map›Paper›PMID 38948746›Full record

ArticlebioRxiv : the preprint server for biology2024

Compositionally unique mitochondria in filopodia support cellular migration.

Madeleine Marlar-Pavey, Daniel Tapias-Gomez, Marcel Mettlen, Jonathan R Friedman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Madeleine Marlar-PaveyDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX.ORCID 0000-0001-5819-0407
Daniel Tapias-GomezDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX.
Marcel MettlenDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX.ORCID 0000-0001-7047-2749
Jonathan R FriedmanDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX.ORCID 0000-0001-8155-2429

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7M
Spatial Organization of the Mitochondrial Inner MembraneR35GM137894 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Jonathan R. Friedman · 2020 to 2026
$3.1M
Spinning Disk Confocal for UT SouthwesternS10OD028630 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2020 to 2020
$600k
TEM for UT Southwestern Electron Microscopy Core FacilityS10OD021685 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2017 to 2017
$398k
NCI NIH HHS P30 CA142543NIGMS NIH HHS R35 GM137894NIH HHS S10 OD021685NIH HHS S10 OD028630
6 · The paper itself

Abstract

Local metabolic demand within cells varies widely and the extent to which individual mitochondria can be specialized to meet these functional needs is unclear. We examined the subcellular distribution of MICOS, a spatial and functional organizer of mitochondria, and discovered that it dynamically enriches at the tip of a minor population of mitochondria in the cell periphery that we term "METEORs". METEORs have a unique composition; MICOS enrichment sites are depleted of mtDNA and matrix proteins and contain high levels of the Ca

Identifiers

PMID38948746
PMCPMC11212966

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.