Evidence map›Paper›PMID 38948732›Full record

ArticlebioRxiv : the preprint server for biology2024

Sex differences and immune correlates of Long COVID development, persistence, and resolution.

Rebecca E Hamlin, Shaun M Pienkos, Leslie Chan, Mikayla A Stabile, Kassandra Pinedo, Mallika Rao, Philip Grant, Hector Bonilla, Marisa Holubar, Upinder Singh and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Rebecca E HamlinDepartment of Medicine, Stanford University School of Medicine; Stanford, CA, USA.ORCID 0000-0001-7336-6028
Shaun M PienkosDepartment of Medicine, Stanford University School of Medicine; Stanford, CA, USA.
Leslie ChanDepartment of Medicine, Stanford University School of Medicine; Stanford, CA, USA.
Mikayla A StabileDepartment of Medicine, Stanford University School of Medicine; Stanford, CA, USA.
Kassandra PinedoDepartment of Medicine, Stanford University School of Medicine; Stanford, CA, USA.
Mallika RaoStanford Center for Clinical Research, Stanford University; Stanford, CA, USA.
Philip GrantDepartment of Medicine, Stanford University School of Medicine; Stanford, CA, USA.
Hector BonillaDepartment of Medicine, Stanford University School of Medicine; Stanford, CA, USA.
Marisa HolubarDepartment of Medicine, Stanford University School of Medicine; Stanford, CA, USA.
Upinder SinghDepartment of Medicine, Stanford University School of Medicine; Stanford, CA, USA.
Karen B JacobsonDepartment of Medicine, Stanford University School of Medicine; Stanford, CA, USA.
Prasanna JagannathanDepartment of Medicine, Stanford University School of Medicine; Stanford, CA, USA.ORCID 0000-0001-6305-758X
Yvonne MaldonadoDepartment of Pediatrics, Stanford University School of Medicine; Stanford, CA, USA.
Susan P HolmesDepartment of Statistics, Stanford University; Stanford, CA, USA.
Aruna SubramanianDepartment of Medicine, Stanford University School of Medicine; Stanford, CA, USA.
Catherine A BlishDepartment of Medicine, Stanford University School of Medicine; Stanford, CA, USA.

Funding

OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository CoreOT2HL161847 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GROSS, RACHEL SHARON, HORWITZ, LEORA · 2021 to 2025
$651.0M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0M
Computational models of naturally acquired immunity to falciparum malariaU01AI150741 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BUTTE, ATUL J, GREENHOUSE, BRYAN R · 2020 to 2024
$7.4M
EMERGING INFECTIOUS DISEASEST32AI007502 · NIAID · STANFORD UNIVERSITY · PI Prasanna Jagannathan, DAVID A. RELMAN · 1995 to 2026
$6.8M
Mentoring translational scientists in international infectious disease researchK24AI144048 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bryan R Greenhouse · 2019 to 2026
$1.6M
Translational Studies of Plasmodium Falciparum Infection DynamicsK23AI076614 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GREENHOUSE, BRYAN R · 2008 to 2012
$609k
NCATS NIH HHS UL1 TR001085NHLBI NIH HHS OT2 HL161847NIAID NIH HHS K23 AI076614NIAID NIH HHS K24 AI144048NIAID NIH HHS T32 AI007290NIAID NIH HHS T32 AI007502NIAID NIH HHS U01 AI150741
6 · The paper itself

Abstract

Sex differences have been observed in acute COVID-19 and Long COVID (LC) outcomes, with greater disease severity and mortality during acute infection in males and a greater proportion of females developing LC. We hypothesized that sex-specific immune dysregulation contributes to the pathogenesis of LC. To investigate the immunologic underpinnings of LC development and persistence, we used single-cell transcriptomics, single-cell proteomics, and plasma proteomics on blood samples obtained during acute SARS-CoV-2 infection and at 3 and 12 months post-infection in a cohort of 45 patients who either developed LC or recovered. Several sex-specific immune pathways were associated with LC. Specifically, males who would develop LC at 3 months had widespread increases in

Identifiers

PMID38948732
PMCPMC11212991

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.