ArticleWorld journal of hepatology2024
Cold ischemia time in liver transplantation: An overview.
Article in World journal of hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Construction and validation of a prediction model for graft failure in pediatric liver transplant recipients based on the APRI-ALBI score: a retrospective study of 289 cases.Annals of medicine · 2026Article
- Preoperative NLR and INR, and intraoperative cold ischemia time as predictors of short-term mortality risk in paediatric liver transplantation: a LASSO-cox model study.Annals of medicine · 2026Article
- Zero Warm Ischemia Time in Whole-Eye Transplantation through Retrograde Extracorporeal Perfusion.Ophthalmology science · 2026Article
- Prolonged Cold Ischemic Time Before Normothermic Machine Perfusion Accentuates Postreperfusion Hepatocellular Injury.Transplantation direct · 2026Article
- The Evolving Role of Living Donor Liver Transplantation in the Management of Colorectal Liver Metastases.Current oncology (Toronto, Ont.) · 2026Review
- Differences in Mortality by Donor Sex and Age in a Multinational Cohort of Liver Transplant Recipients.Transplantation direct · 2026Article
- Ischemic preconditioning promotes hepatic differentiation in human liver organoids.Frontiers in cell and developmental biology · 2026Article
- Protective effects of treprostinil and ischemic preconditioning on hepatic ischemia-reperfusion injury and biomarkers in experimental studies in rats.World journal of gastrointestinal surgery · 2025Article
- Comparison of time-to-event machine learning models in predicting biliary complication and mortality rate in liver transplant patients.Scientific reports · 2025Article
- Molecular Mechanisms of Ischemia/Reperfusion Injury and Graft Dysfunction in Liver Transplantation: Insights from Multi-Omics Studies in Rodent Animal Models.International journal of biological sciences · 2025Review
- Cryopreservation of hepatocytes: Impact of long-term storage and organ donor factors on cell quality for clinical applications.Cell transplantationArticle
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Authors and funding
5 authors.
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Abstract
The standard approach to organ preservation in liver transplantation is by static cold storage and the time between the cross-clamping of a graft in a donor and its reperfusion in the recipient is defined as cold ischemia time (CIT). This simple definition reveals a multifactorial time frame that depends on donor hepatectomy time, transit time, and recipient surgery time, and is one of the most important donor-related risk factors which may influence the graft and recipient's survival. Recently, the growing demand for the use of marginal liver grafts has prompted scientific exploration to analyze ischemia time factors and develop different organ preservation strategies. This review details the CIT definition and analyzes its different factors. It also explores the most recent strategies developed to implement each timestamp of CIT and to protect the graft from ischemic injury.
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