Evidence map›Paper›PMID 38948322›Full record

ArticleLancet regional health. Americas2024

Impact of pre-operative abdominal MRI on survival for patients with resected pancreatic carcinoma: a population-based study.

Amer Alaref, Dylan Siltamaki, Joshua O Cerasuolo, Noori Akhtar-Danesh, Joseph M Caswell, Pablo E Serrano, Brandon M Meyers, David W Savage, Jennifer Nelli, Michael Patlas and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lancet regional health. Americas, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amer AlarefNOSM University, Thunder Bay, Ontario, Canada.
Dylan SiltamakiNOSM University, Thunder Bay, Ontario, Canada.
Joshua O CerasuoloICES North, Health Sciences North Research Institute, Sudbury, Ontario, Canada.
Noori Akhtar-DaneshICES McMaster, Faculty of Health Sciences, Hamilton, Ontario, Canada.
Joseph M CaswellICES North, Health Sciences North Research Institute, Sudbury, Ontario, Canada.
Pablo E SerranoMcMaster University, Hamilton, Ontario, Canada.
Brandon M MeyersMcMaster University, Hamilton, Ontario, Canada.
David W SavageNOSM University, Thunder Bay, Ontario, Canada.
Jennifer NelliMcMaster University, Hamilton, Ontario, Canada.
Michael PatlasUniversity of Toronto, Toronto, Ontario, Canada.
Abdullah AlabousiMcMaster University, Hamilton, Ontario, Canada.
Rabail SiddiquiThunder Bay Regional Health Research Institute, Thunder Bay, Ontario, Canada.
Christian B van der PolMcMaster University, Hamilton, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study determined the impact of pre-operative abdominal MRI on all-cause mortality for patients with resected PDAC. Methods: All adult (≥18 years) PDAC patients who underwent pancreatectomy between January 2011 and December 2022 in Ontario, Canada, were identified for this population-based cohort study (ICD-O-3 codes: C250, C251, C252, C253, C257, C258). Patient demographics, comorbidities, PDAC stage, medical and surgical management, and survival data were sourced from multiple linked provincial administrative databases at ICES. All-cause mortality was compared between patients with and without a pre-operative abdominal MRI after controlling for multiple covariates. Findings: A cohort of 4579 patients consisted of 2432 men (53.1%) and 2147 women (46.9%) with a mean age of 65.2 years (standard deviation: 11.2 years); 2998 (65.5%) died while 1581 (34.5%) survived. Median follow-up duration post-resection was 22.4 months (interquartile range: 10.8-48.8 months), and median survival post-pancreatectomy was 25.9 months (95% confidence interval [95% CI]: 24.8, 27.5). Patients who underwent a pre-operative abdominal MRI had a median survival of 33.1 months (95% CI: 30.7, 37.2) compared to 21.1 months (95% CI: 19.8, 22.6) for all others. A total of 2354/4579 (51.4%) patients underwent a pre-operative abdominal MRI, which was associated with a 17.2% (95% CI: 11.0, 23.1) decrease in the rate of all-cause mortality, with an adjusted hazard ratio (aHR) of 0.828 (95% CI: 0.769, 0.890). Interpretation: Pre-operative abdominal MRI was associated with improved overall survival for PDAC patients who underwent pancreatectomy, possibly due to better detection of liver metastases than CT. Funding: Northern Ontario Academic Medicine Association (NOAMA) Clinical Innovation Fund.

Indexed as

CarcinomaMagnetic resonance imagingPancreatectomyPancreatic ductalPancreatic neoplasmsSurvival analysis

Identifiers

PMID38948322
PMCPMC11214329

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.