Evidence map›Paper›PMID 38948320›Full record

ReviewAnalytical science advances2024

Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives.

Pauline Couacault, Dennisse Avella, Sara Londoño-Osorio, Ana S Lorenzo, Ana Gradillas, Olli Kärkkäinen, Elizabeth Want, Michael Witting

Abstract readReview
In one paragraph

Review in Analytical science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. RPLC- and HILIC-based non-targeted metabolomics workflow for blood microsamples.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pauline CouacaultMetabolomics and Proteomics Core Helmholtz Zentrum München Neuherberg Germany.
Dennisse AvellaAfekta Technologies Ltd. Kuopio Finland.
Sara Londoño-OsorioCentro de Metabolómica y Bioanálisis (CEMBIO) Facultad de Farmacia Universidad San Pablo-CEU CEU Universities Urbanización Montepríncipe Boadilla del Monte Madrid Spain.
Ana S LorenzoDepartment of Metabolism Digestion and Reproduction Imperial College London London UK.
Ana GradillasCentro de Metabolómica y Bioanálisis (CEMBIO) Facultad de Farmacia Universidad San Pablo-CEU CEU Universities Urbanización Montepríncipe Boadilla del Monte Madrid Spain.
Olli KärkkäinenAfekta Technologies Ltd. Kuopio Finland.
Elizabeth WantDepartment of Metabolism Digestion and Reproduction Imperial College London London UK.
Michael WittingMetabolomics and Proteomics Core Helmholtz Zentrum München Neuherberg Germany.ORCID https://orcid.org/0000-0002-1462-4426

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood microsampling (BµS) offers an alternative to conventional methods that use plasma or serum for profiling human health, being minimally invasive and cost effective, especially beneficial for vulnerable populations. We present a non-systematic review that offers a synopsis of the analytical methods, applications and perspectives related to dry blood microsampling in targeted and untargeted metabolomics and lipidomics research in the years 2022 and 2023. BµS shows potential in neonatal and paediatric studies, therapeutic drug monitoring, metabolite screening, biomarker research, sports supervision, clinical disorders studies and forensic toxicology. Notably, dried blood spots and volumetric absorptive microsampling options have been more extensively studied than other volumetric technologies. Therefore, we suggest that a further investigation and application of the volumetric technologies will contribute to the use of BµS as an alternative to conventional methods. Conversely, we support the idea that harmonisation of the analytical methods when using BµS would have a positive impact on its implementation.

Indexed as

blood microsamplingdried bloodLC–MS analysislipidomicsmetabolomicstargeted and untargeted

Identifiers

PMID38948320
PMCPMC11210747

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.