Evidence map›Paper›PMID 38948270›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2024

[Sanshentongmai Mixture Improves Oxidative Damage in Rat Cardiomyocytes H9C2 via Upregulation of microRNA-146a].

Ran Li, Zhenyu Wang, Yanli Wang, Fei Teng

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ran Li（ 100010） Department of Health Care for Cadres, Beijing Hospital of Traditional Chinese Medicine Affiliated to the Capital Medical University, Beijing 100010, China.
Zhenyu Wang（ 100010） Department of Health Care for Cadres, Beijing Hospital of Traditional Chinese Medicine Affiliated to the Capital Medical University, Beijing 100010, China.
Yanli Wang（ 100010） Department of Health Care for Cadres, Beijing Hospital of Traditional Chinese Medicine Affiliated to the Capital Medical University, Beijing 100010, China.
Fei Teng（ 100010） Department of Health Care for Cadres, Beijing Hospital of Traditional Chinese Medicine Affiliated to the Capital Medical University, Beijing 100010, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the effect of Sanshentongmai (SSTM) mixture on the regulation of oxidative damage to rat cardiomyocytes (H9C2) through microRNA-146a and its mechanism. Methods: H9C2 were cultured Result: H9C2 cells were pretreated with SSTM at mass concentrations ranging from 200 to 1500 μg/L. Then, CCK8 assay was performed to measure cell viability and the findings showed that the improvement in cell proliferation reached its peak when the mass concentration of SSTM was 500 μg/L, which was subsequently used as the intervention concentration. ELISA was performed to measure the indicators related to heart failure, including Nt-proBNP, NO, Hs-CRP, and angiotensin Ⅱ. Compared with those of the control group, the expressions of Nt-proBNP and angiotensin Ⅱ in the treatment group were up-regulated ( Conclusion: SSTM can significantly resist the H

Indexed as

Drugs, Chinese HerbalHydrogen PeroxideMicroRNAsMyocytes, CardiacOxidative StressUp-RegulationAnimalsCell LineCell SurvivalDrug CombinationsRatsDrug CombinationsDrugs, Chinese Herbalfructus schizandrae, radix ginseng, radix ophiopogonis drug combinationHydrogen PeroxideMicroRNAsMIRN146a microRNA, ratMIRN146 microRNA, ratH9C2 cell linemicroRNA-146aOxidative damageSanshentongmai mixture

Identifiers

PMID38948270
PMCPMC11211798

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.