Evidence map›Paper›PMID 38948254›Full record

ArticleBioactive materials2024

Regulating the proinflammatory response to composite biomaterials by targeting immunometabolism.

Chima V Maduka, Ashley V Makela, Anthony Tundo, Evran Ural, Katlin B Stivers, Maxwell M Kuhnert, Mohammed Alhaj, Ehsanul Hoque Apu, Nureddin Ashammakhi, Kurt D Hankenson and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  9. Review
  10. Review
  11. Engineering the Immune Response to Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chima V MadukaComparative Medicine & Integrative Biology, Michigan State University, East Lansing, MI, 48824, USA.
Ashley V MakelaDepartment of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Anthony TundoDepartment of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Evran UralDepartment of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Katlin B StiversTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Maxwell M KuhnertDepartment of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Mohammed AlhajDepartment of Chemical Engineering & Materials Science, Michigan State University, East Lansing, MI, 48824, USA.
Ehsanul Hoque ApuDepartment of Biomedical Sciences, College of Dental Medicine, Lincoln Memorial University, Knoxville, TN, 37917, USA.
Nureddin AshammakhiDepartment of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Kurt D HankensonDepartment of Orthopedic Surgery, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Ramani NarayanDepartment of Chemical Engineering & Materials Science, Michigan State University, East Lansing, MI, 48824, USA.
Jennifer H ElisseeffTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Christopher H ContagDepartment of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, 48824, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Composite biomaterials comprising polylactide (PLA) and hydroxyapatite (HA) are applied in bone, cartilage and dental regenerative medicine, where HA confers osteoconductive properties. However, after surgical implantation, adverse immune responses to these composites can occur, which have been attributed to size and morphology of HA particles. Approaches to effectively modulate these adverse immune responses have not been described. PLA degradation products have been shown to alter immune cell metabolism (immunometabolism), which drives the inflammatory response. Accordingly, to modulate the inflammatory response to composite biomaterials, inhibitors were incorporated into composites comprised of amorphous PLA (aPLA) and HA (aPLA + HA) to regulate glycolytic flux. Inhibition at specific steps in glycolysis reduced proinflammatory (CD86

Indexed as

HydroxyapatiteImmunometabolismInflammationPolylactideRegenerative medicine

Identifiers

PMID38948254
PMCPMC11214186

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.