ArticleNature. Mental health2024
Neuroanatomical dimensions in medication-free individuals with major depressive disorder and treatment response to SSRI antidepressant medications or placebo.
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Article in Nature. Mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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22citing papers in PubMed, 2 pooled it
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Machine Learning for Comparative Antidepressant Selection in Major Depressive Disorder: Systematic Review.JMIR mental health · 2026Pooled it
- Attachment Styles in Major Depressive Disorder: A Systematic Review and Meta-Analysis.Clinical psychology & psychotherapyPooled it
- Neurophysiological Correlates of Neuroanatomical Dimensions in Major Depressive Disorder: Electroencephalographic Markers of Brain Function and Treatment Outcome.Biological psychiatry global open science · 2026Article
- Neurobiological subtypes in alcohol use disorder and their phenotypic and clinical profiles.Molecular psychiatry · 2026Article
- Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.Translational psychiatry · 2026Article
- Sigma-1R-CD36 axis in myeloid cells contributes to the alleviation of depression-like behaviors.Journal of translational medicine · 2026Article
- Multi-organ AI endophenotypes chart the heterogeneity of brain, eye and heart pan-disease.Nature. Mental health · 2026Article
- Beyond depression symptoms: the default mode network as a predictor of antidepressant response.Npj mental health research · 2026Article
- Generalizable structure-function covariation predictive of antidepressant response revealed by target-oriented multimodal fusion.Nature. Mental health · 2026Article
- Measurement of Serum Parameters Attributes the Therapeutic Effects of Music Therapy to Augmented Stress-Coping Ability and Diminished Systemic Inflammation.Depression and anxiety · 2026Article
- Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics.Communications medicine · 2025Article
- Article
- Dissecting real-world memory clinical cohort heterogeneity: analysis of neuroanatomical subtypes using HYDRA.Alzheimer's research & therapy · 2025Article
- Article
- Blood immuno-metabolic biomarker signatures of depression and affective symptoms in young adults.Brain, behavior, and immunity · 2025Article
- Contrastive functional connectivity defines neurophysiology-informed symptom dimensions in major depression.Cell reports. Medicine · 2025Article
- Biomarkers of cognitive and memory decline in psychotropic drug users.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Advancing depression treatment: the role of sigma receptor ligands.Frontiers in neuroscience · 2025Review
- Trends in research on novel antidepressant treatments.Frontiers in pharmacology · 2025Review
- Towards closed-loop precision psychiatry: Integrating MRI biomarkers for individualized care of major depressive disorder.Psychoradiology · 2025Review
Corrections and comments
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Authors and funding
49 authors.
Cynthia H Y Fu *School of Psychology, University of East London, London, UK.ORCID 0000-0003-4313-3500
Mathilde Antoniades *Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.ORCID 0000-0002-8241-835X
Guray ErusCenter for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
Jose A GarciaCenter for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
Yong FanCenter for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
Danilo ArnoneCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Stephen R ArnottRotman Research Institute, Baycrest Centre, Toronto, Ontario Canada.ORCID 0000-0002-0616-7771
Taolin ChenHuaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
Ki Sueng ChoiNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY USA.ORCID 0000-0002-6446-0677
Cherise Chin FattDepartment of Psychiatry, Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX USA.
Benicio N FreyDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario Canada.ORCID 0000-0001-8267-943X
Vibe G FrokjaerNeurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark.
Melanie GanzSchool of Psychology, University of East London, London, UK.ORCID 0000-0002-9120-8098
Beata R GodlewskaDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0002-5973-3765
Stefanie HasselMathison Centre for Mental Health Research and Education, University of Calgary, Calgary, Alberta Canada.ORCID 0000-0001-7240-1581
Keith HoDepartment of Psychiatry, University Health Network, Toronto, Ontario Canada.
Andrew M McIntoshDivision of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-0198-4588
Kun QinHuaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
Susan RotzingerDepartment of Psychiatry, University Health Network, Toronto, Ontario Canada.
Matthew D SacchetMeditation Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA.
Jonathan SavitzLaureate Institute for Brain Research, Tulsa, OK USA.ORCID 0000-0001-8143-182X
Haochang ShouCenter for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
Ashish SinghCenter for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.ORCID 0000-0003-4486-3636
Aleks StolicynDivision of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-1147-7539
Irina StrigoDepartment of Psychiatry, University of California San Francisco, San Francisco, USA.
Stephen C StrotherRotman Research Institute, Baycrest Centre, Toronto, Ontario Canada.
Duygu TosunDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA USA.ORCID 0000-0001-8644-7724
Teresa A VictorLaureate Institute for Brain Research, Tulsa, OK USA.
Dongtao WeiSchool of Psychology, Southwest University, Chongqing, China.
Toby WiseDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Roland ZahnCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID 0000-0002-8447-1453
Ian M AndersonDivision of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.
W Edward CraigheadDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA USA.ORCID 0000-0001-9957-0027
J F William DeakinDivision of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.
Boadie W DunlopDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA USA.ORCID 0000-0002-4653-0483
Rebecca ElliottDivision of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.
Qiyong GongHuaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0002-5912-4871
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, CA USA.
Catherine J HarmerDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0002-1609-8335
Sidney H KennedyDepartment of Psychiatry, University Health Network, Toronto, Ontario Canada.ORCID 0000-0001-5339-7185
Gitte M KnudsenNeurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0003-1508-6866
Helen S MaybergNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY USA.ORCID 0000-0002-1672-2716
Martin P PaulusLaureate Institute for Brain Research, Tulsa, OK USA.ORCID 0000-0002-0825-3606
Jiang QiuSchool of Psychology, Southwest University, Chongqing, China.
Madhukar H TrivediDepartment of Psychiatry, Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX USA.ORCID 0000-0002-2983-1110
Heather C WhalleyDivision of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.
Chao-Gan YanKey Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0003-3413-5977
Allan H YoungCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Christos DavatzikosCenter for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.ORCID 0000-0002-1025-8561
Funding
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7MThe Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI Jonathan Savitz · 2017 to 2026
$23.7MUltrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7MEstablishing Moderators/Biosignatures of Antidepressant Response- Clinical CareU01MH092221 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TRIVEDI, MADHUKAR H. · 2010 to 2015
$9.7MSpecial Scientific Procedures: Statistical Modeling CoreP50MH077083 · NIMH · EMORY UNIVERSITY · PI KUTNER, MICHAEL HENRY · 2006 to 2010
$9.3MBiosignatures of Treatment Remission in Major DepressionU01MH092250 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MCGRATH, PATRICK J, PARSEY, RAMIN V. · 2010 to 2015
$8.9MPsychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across AdolescenceR37MH101495 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB · 2018 to 2026
$6.6MPredictors of Treatment Response Relapse and Recurrence in Major DepressionR01MH080880 · NIMH · EMORY UNIVERSITY · PI CRAIGHEAD, W. EDWARD · 2008 to 2012
$6.6MMachine Learning and Large-scale Imaging analytics for dimensional representations of brain trajectories in aging and preclinical Alzheimer's Disease: The brain aging chart and the iSTAGING consortiumRF1AG054409 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2023
$6.3MPersonalized Functional Network Modeling to Characterize and Predict Psychopathology in YouthR01EB022573 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Yong Fan, Theodore Satterthwaite · 2016 to 2026
$6.0MHarmonization of Multi-Site Neuroimaging Data from Complex Study DesignsR01MH123550 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2020 to 2025
$4.0MFast and robust deep learning tools for analysis of neuroimaging data of Alzheimer's diseaseR01AG066650 · NIA · UNIVERSITY OF PENNSYLVANIA · PI FAN, YONG · 2021 to 2025
$3.4MMedical Research Council G0902304Medical Research Council MR/T017538/1NIA NIH HHS R01 AG066650NIA NIH HHS RF1 AG054409NIA NIH HHS U01 AG068057NIBIB NIH HHS R01 EB022573NIDA NIH HHS U01 DA041089NIGMS NIH HHS P20 GM121312NIMH NIH HHS K01 MH096077NIMH NIH HHS P50 MH077083NIMH NIH HHS R01 MH080880NIMH NIH HHS R01 MH098099NIMH NIH HHS R01 MH101472NIMH NIH HHS R01 MH112070NIMH NIH HHS R01 MH123550NIMH NIH HHS R01 MH125850NIMH NIH HHS R01 MH134236NIMH NIH HHS R37 MH101495NIMH NIH HHS U01 MH092221NIMH NIH HHS U01 MH092250Wellcome Trust
Abstract
Major depressive disorder (MDD) is a heterogeneous clinical syndrome with widespread subtle neuroanatomical correlates. Our objective was to identify the neuroanatomical dimensions that characterize MDD and predict treatment response to selective serotonin reuptake inhibitor (SSRI) antidepressants or placebo. In the COORDINATE-MDD consortium, raw MRI data were shared from international samples (
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