Evidence map›Paper›PMID 38948192›Full record

ArticleImaging science in dentistry2024

Beyond the mouth: Uncovering non-secretory multiple myeloma through oral symptoms.

Pedro Henrique Chaves Isaias, Fábio Wildson Gurgel Costa, Pedro Henrique Gonçalves Holanda Amorim, Raul Anderson Domingues Alves da Silva, Fabrício Bitu Sousa, Karuza Maria Alves Pereira, Ana Paula Negreiros Nunes Alves, Mário Rogério Lima Mota

Abstract readCase Reports
In one paragraph

Article in Imaging science in dentistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pedro Henrique Chaves IsaiasDepartment of Dental Clinic, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0003-4399-1302
Fábio Wildson Gurgel CostaDepartment of Dental Clinic, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0002-3262-3347
Pedro Henrique Gonçalves Holanda AmorimDepartment of Dentistry, Catholic University Center of Quixadá, Quixadá, Ceará, Brazil.ORCID https://orcid.org/0009-0000-3194-036X
Raul Anderson Domingues Alves da SilvaDepartment of Dentistry, Christus University Center, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0002-7625-3595
Fabrício Bitu SousaDepartment of Dental Clinic, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0002-6430-9475
Karuza Maria Alves PereiraDepartment of Dental Clinic, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0002-2880-6466
Ana Paula Negreiros Nunes AlvesDepartment of Dental Clinic, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0002-5090-6877
Mário Rogério Lima MotaDepartment of Dental Clinic, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0003-3778-0584

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-secretory multiple myeloma (NSMM) is a rare cancer of plasma cells characterized by the absence of detectable monoclonal M protein in the blood or urine. A 57-year-old woman presented with mandibular pain but without intraoral swelling. Imaging studies revealed multiple osteolytic lesions in her mandible and pronounced root resorption of the left mandibular second molar. Biopsy results showed atypical plasmacytoid cells positive for anti-kappa, CD138, MUM1, and CD79a antibodies, but negative for anti-lambda and CD20. These results were indicative of a malignant plasma cell neoplasm. No abnormalities were revealed by free light chain assay or by serum or urine protein electrophoresis, leading to a diagnosis of NSMM. The patient began chemotherapy in conjunction with bisphosphonate therapy and achieved remission following treatment. This case underscores the critical role of dentists in the early detection and prevention of NSMM complications, as the disease can initially present in the oral cavity.

Indexed as

ImmunohistochemistryJawMultiple MyelomaRadiography, Panoramic

Identifiers

PMID38948192
PMCPMC11211024

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.