Evidence map›Paper›PMID 38948131›Full record

ArticleRegenerative therapy2024

Skeletal muscle injury treatment using the Silk Elastin® injection in a rat model.

Kyohei Nakata, Masakazu Ishikawa, Naosuke Kamei, Shigeru Miyaki, Nobuo Adachi, Keiichiro Inoue, Shingo Kawabata

Abstract read
In one paragraph

Article in Regenerative therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kyohei NakataDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University Hospital, Japan.
Masakazu IshikawaDepartment of Orthopaedic Surgery, Faculty of Medicine, Kagawa University Hospital, Japan.
Naosuke KameiDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University Hospital, Japan.
Shigeru MiyakiMedical Center for Translational and Clinical Research, Hiroshima University Hospital, Japan.
Nobuo AdachiDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University Hospital, Japan.
Keiichiro InoueSanyo Chemical Industries, LTD., Japan.
Shingo KawabataSanyo Chemical Industries, LTD., Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Skeletal muscle injury (SMI) is often treated conservatively, although it can lead to scar tissue formation, which impedes muscle function and increases muscle re-injury risk. However, effective interventions for SMIs are yet to be established. Hypothesis: The administration of Silk Elastin® (SE), a novel artificial protein, to the SMI site can suppress scar formation and promote tissue repair. Study design: A controlled laboratory study. Methods: Results: Conclusion: Injection of SE gel to the SMI site may inhibit tissue scarring by reducing excessive fibroblast migration, thereby enhancing tissue repair. Clinical relevance: The findings of this study may contribute to the development of an early intervention method for SMIs.

Indexed as

FibrosisInjuryMaterialSkeletal muscle

Identifiers

PMID38948131
PMCPMC11214263

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.