Evidence map›Paper›PMID 38948114›Full record

ReviewMedComm2024

Membranous nephropathy: pathogenesis and treatments.

Mengqiong Wang, Jingjuan Yang, Xin Fang, Weiqiang Lin, Yi Yang

Abstract readReview
In one paragraph

Review in MedComm, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mengqiong WangDepartment of Nephrology Center for Regeneration and Aging Medicine The Fourth Affiliated Hospital of School of Medicine and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China.
Jingjuan YangDepartment of Nephrology Center for Regeneration and Aging Medicine The Fourth Affiliated Hospital of School of Medicine and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China.
Xin FangDepartment of Nephrology Center for Regeneration and Aging Medicine The Fourth Affiliated Hospital of School of Medicine and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China.
Weiqiang LinDepartment of Nephrology Center for Regeneration and Aging Medicine The Fourth Affiliated Hospital of School of Medicine and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China.
Yi YangDepartment of Nephrology Center for Regeneration and Aging Medicine The Fourth Affiliated Hospital of School of Medicine and International School of Medicine, International Institutes of Medicine Zhejiang University Yiwu China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membranous nephropathy (MN), an autoimmune disease, can manifest at any age and is among the most common causes of nephrotic syndrome in adults. In 80% of cases, the specific etiology of MN remains unknown, while the remaining cases are linked to drug use or underlying conditions like systemic lupus erythematosus, hepatitis B virus, or malignancy. Although about one-third of patients may achieve spontaneous complete or partial remission with conservative management, another third face an elevated risk of disease progression, potentially leading to end-stage renal disease within 10 years. The identification of phospholipase A2 receptor as the primary target antigen in MN has brought about a significant shift in disease management and monitoring. This review explores recent advancements in the pathophysiology of MN, encompassing pathogenesis, clinical presentations, diagnostic criteria, treatment options, and prognosis, with a focus on emerging developments in pathogenesis and therapeutic strategies aimed at halting disease progression. By synthesizing the latest research findings and clinical insights, this review seeks to contribute to the ongoing efforts to enhance our understanding and management of this challenging autoimmune disorder.

Indexed as

antigenic epitopeHLAkidney pathogenesismembranous nephropathyPLA2R

Identifiers

PMID38948114
PMCPMC11214595

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.