Evidence map›Paper›PMID 38948062›Full record

ArticleTheranostics2024

Towards effective CAIX-targeted radionuclide and checkpoint inhibition combination therapy for advanced clear cell renal cell carcinoma.

Simone C Kleinendorst, Egbert Oosterwijk, Janneke Molkenboer-Kuenen, Cathelijne Frielink, Gerben M Franssen, Daan F Boreel, Giulia Tamborino, Manon Gloudemans, Merel Hendrikx, Dennis Kroon and 8 more

Abstract read
In one paragraph

Article in Theranostics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The molecular blueprint of targeted radionuclide therapy.Nature reviews. Clinical oncology · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Simone C KleinendorstDepartment of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Egbert OosterwijkDepartment of Urology, Radboud University Medical Center, Nijmegen, the Netherlands.
Janneke Molkenboer-KuenenDepartment of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Cathelijne FrielinkDepartment of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Gerben M FranssenDepartment of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Daan F BoreelDepartment of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Giulia TamborinoDepartment of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.
Manon GloudemansDepartment of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Merel HendrikxDepartment of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Dennis KroonDepartment of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Jopp HillenDepartment of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Johan BussinkDepartment of Radiation Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
Stijn MuselaersDepartment of Urology, Radboud University Medical Center, Nijmegen, the Netherlands.
Peter MuldersDepartment of Urology, Radboud University Medical Center, Nijmegen, the Netherlands.
Mark W KonijnenbergDepartment of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Michael P WheatcroftTelix Pharmaceuticals Limited, Melbourne, VIC 3051, Australia.
Kwame Twumasi-BoatengTelix Pharmaceuticals Limited, Melbourne, VIC 3051, Australia.
Sandra HeskampDepartment of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Carbonic Anhydrase IXCarcinoma, Renal CellImmune Checkpoint InhibitorsKidney NeoplasmsAnimalsAntibodies, MonoclonalAntigens, NeoplasmCell Line, TumorCombined Modality TherapyFemaleHumansLutetiumMiceMice, Inbred BALB CRadioisotopesTissue DistributionAntibodies, MonoclonalAntigens, NeoplasmCA9 protein, humanCarbonic Anhydrase IXG250 monoclonal antibodyImmune Checkpoint InhibitorsLutetiumLutetium-177RadioisotopesTpt1 protein, mouseTumor Protein, Translationally-Controlled 1Cancer TreatmentCombined Modality TherapyImmune Checkpoint InhibitorsTargeted Radionuclide TherapyTumor Microenvironment

Identifiers

PMID38948062
PMCPMC11209717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.