Evidence map›Paper›PMID 38947970›Full record

ReviewWorld journal of transplantation2024

Whole-eye transplantation: Current challenges and future perspectives.

Anna Scarabosio, Pier Luigi Surico, Vlad Tereshenko, Rohan Bir Singh, Carlo Salati, Leopoldo Spadea, Glenda Caputo, Pier Camillo Parodi, Caterina Gagliano, Jonathan M Winograd and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anna ScarabosioDepartment of Plastic Surgery, University Hospital of Udine, Udine 33100, Italy.
Pier Luigi SuricoSchepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, United States.
Vlad TereshenkoDepartment of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.
Rohan Bir SinghSchepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, United States.
Carlo SalatiDepartment of Ophthalmology, University Hospital of Udine, Udine 33100, Italy.
Leopoldo SpadeaEye Clinic, Policlinico Umberto I, "Sapienza" University of Rome, Rome 00142, Italy.
Glenda CaputoDepartment of Plastic Surgery, University Hospital of Udine, Udine 33100, Italy.
Pier Camillo ParodiDepartment of Plastic Surgery, University Hospital of Udine, Udine 33100, Italy.
Caterina GaglianoDepartment of Medicine and Surgery, University of Enna "Kore", Enna 94100, Italy.
Jonathan M WinogradDepartment of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.
Marco ZeppieriDepartment of Ophthalmology, University Hospital of Udine, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whole-eye transplantation emerges as a frontier in ophthalmology, promising a transformative approach to irreversible blindness. Despite advancements, formidable challenges persist. Preservation of donor eye viability post-enucleation necessitates meticulous surgical techniques to optimize retinal integrity and ganglion cell survival. Overcoming the inhibitory milieu of the central nervous system for successful optic nerve regeneration remains elusive, prompting the exploration of neurotrophic support and immunomodulatory interventions. Immunological tolerance, paramount for graft acceptance, confronts the distinctive immunogenicity of ocular tissues, driving research into targeted immunosuppression strategies. Ethical and legal considerations underscore the necessity for stringent standards and ethical frameworks. Interdisciplinary collaboration and ongoing research endeavors are imperative to navigate these complexities. Biomaterials, stem cell therapies, and precision immunomodulation represent promising avenues in this pursuit. Ultimately, the aim of this review is to critically assess the current landscape of whole-eye transplantation, elucidating the challenges and advancements while delineating future directions for research and clinical practice. Through concerted efforts, whole-eye transplantation stands to revolutionize ophthalmic care, offering hope for restored vision and enhanced quality of life for those afflicted with blindness.

Indexed as

EyeImmunological toleranceNerve regenerationOptic nerveTransplantation

Identifiers

PMID38947970
PMCPMC11212585

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.