Evidence map›Paper›PMID 38947883›Full record

ArticleNature cardiovascular research2023

CCR2 Imaging in Human ST-Segment Elevation Myocardial Infarction.

Kory J Lavine, Deborah Sultan, Hannah Luehmann, Lisa Detering, Xiaohui Zhang, Gyu Seong Heo, Xiuli Zhang, Michelle Hoelscher, Kitty Harrison, Christophe Combadière and 6 more

Abstract read
In one paragraph

Article in Nature cardiovascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. PET Imaging in Pulmonary Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  2. Immuno-positron emission tomography in cardiovascular disease: Advances, challenges, and opportunities.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2026
    Review
  3. Assessment of CCR2 PET as a Biomarker for Head and Neck Squamous Cell Carcinoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  4. Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  5. Molecular contrast agents for post-infarct cardiac remodelling: a contemporary review.European heart journal. Imaging methods and practice · 2026
    Review
  6. Review
  7. Review
  8. Advances in molecular imaging for osteoarthritis.Connective tissue research · 2025
    Review
  9. Article
  10. Review
  11. Emerging PET radiotracers for vascular imaging.Rheumatology (Oxford, England) · 2025
    Review
  12. Review
  13. Molecular imaging of macrophage composition and dynamics in MASLD.JHEP reports : innovation in hepatology · 2024
    Article
  14. Article
  15. Viability assessment in an evolving field of heart failure treatment: still needed?The international journal of cardiovascular imaging · 2024
    Article
  16. Review
  17. Review
  18. Development of a CCR2 targetedNuclear medicine and biology
    Article
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Kory J LavineDepartment of Medicine, Washington University School of Medicine, St. Louis, MO USA.
Deborah SultanDepartment of Radiology, Washington University School of Medicine, St. Louis, MO USA.
Hannah LuehmannDepartment of Radiology, Washington University School of Medicine, St. Louis, MO USA.
Lisa DeteringDepartment of Radiology, Washington University School of Medicine, St. Louis, MO USA.
Xiaohui ZhangDepartment of Radiology, Washington University School of Medicine, St. Louis, MO USA.
Gyu Seong HeoDepartment of Radiology, Washington University School of Medicine, St. Louis, MO USA.
Xiuli ZhangDepartment of Radiology, Washington University School of Medicine, St. Louis, MO USA.
Michelle HoelscherDepartment of Radiology, Washington University School of Medicine, St. Louis, MO USA.
Kitty HarrisonDepartment of Radiology, Washington University School of Medicine, St. Louis, MO USA.
Christophe CombadièreSorbonne Université, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, F-75013 Paris, France.
Richard LaforestDepartment of Radiology, Washington University School of Medicine, St. Louis, MO USA.
Daniel KreiselDepartment of Immunology and Pathology, Washington University School of Medicine, St. Louis, MO USA.
Pamela K WoodardDepartment of Radiology, Washington University School of Medicine, St. Louis, MO USA.
Steven L BrodyDepartment of Medicine, Washington University School of Medicine, St. Louis, MO USA.
Robert J GroplerDepartment of Medicine, Washington University School of Medicine, St. Louis, MO USA.
Yongjian LiuDepartment of Radiology, Washington University School of Medicine, St. Louis, MO USA.

Funding

Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Buck E. Rogers · 2018 to 2026
$12.7M
Targeted Molecular Probes for Atherosclerosis Imaging and TherapyR35HL145212 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2019 to 2025
$5.1M
Specification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart FailureR35HL161185 · NHLBI · WASHINGTON UNIVERSITY · PI Kory J. Lavine · 2022 to 2026
$4.3M
Molecular Imaging CCR2 Lung Inflammation and FibrosisR01HL151685 · NHLBI · WASHINGTON UNIVERSITY · PI BRODY, STEVEN · 2021 to 2025
$3.7M
PET Detection of CCR2 in Human AtherosclerosisR01HL150891 · NHLBI · WASHINGTON UNIVERSITY · PI GROPLER, ROBERT J., WOODARD, PAMELA K · 2020 to 2024
$3.7M
CCR2 Targeted Molecular Imaging and Treatment of Abdominal Aortic AneurysmsR01HL153436 · NHLBI · WASHINGTON UNIVERSITY · PI GROPLER, ROBERT J., ZAYED, MOHAMED A. · 2020 to 2023
$3.0M
The Role of Donor Innate Immune Responses in Regulating Alloimmunity after Heart TransplantationR01HL151078 · NHLBI · WASHINGTON UNIVERSITY · PI KREISEL, DANIEL, LAVINE, KORY J. · 2020 to 2023
$2.6M
NHLBI NIH HHS R01 HL150891NHLBI NIH HHS R01 HL151078NHLBI NIH HHS R01 HL151685NHLBI NIH HHS R01 HL153436NHLBI NIH HHS R35 HL145212NHLBI NIH HHS R35 HL161185NIBIB NIH HHS P41 EB025815
6 · The paper itself

Abstract

Among the diverse populations of myeloid cells that reside within the healthy and diseased heart, C-C chemokine receptor 2 (CCR2) is specifically expressed on inflammatory populations of monocytes and macrophages that contribute to the development and progression of heart failure

Indexed as

CC Chemokine Receptor 2 (CCR2)MacrophageMolecular ImagingMonocyteMyocardial InfarctionPositron emission tomography

Identifiers

PMID38947883
PMCPMC11210834

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.