Evidence map›Paper›PMID 38947532›Full record

ArticleChem2024

Poison to Promise: The Resurgence of Organophosphorus Fluoride Chemistry.

William P Chappell, Natalie Schur, James A Vogel, Glenn M Sammis, Patrick R Melvin, Nicholas D Ball

Erratum issuedAbstract read
In one paragraph

Article in Chem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

William P ChappellDepartment of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, V6T 1Z1, Canada.
Natalie SchurDepartment of Chemistry, Pomona College, 645 North College Avenue, Claremont, California 91711, United States of America.
James A VogelDepartment of Chemistry, Bryn Mawr College, Bryn Mawr, Pennsylvania 19010, United States of America.
Glenn M SammisDepartment of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, V6T 1Z1, Canada.
Patrick R MelvinDepartment of Chemistry, Bryn Mawr College, Bryn Mawr, Pennsylvania 19010, United States of America.
Nicholas D BallDepartment of Chemistry, Pomona College, 645 North College Avenue, Claremont, California 91711, United States of America.

Funding

Sulfur-Fluoride Exchange (SuFEx) Reactions toward Nitrogen-Based Sulfur(VI) CompoundsR15GM134457 · NIGMS · POMONA COLLEGE · PI BALL, NICHOLAS D · 2020 to 2025
$822k
NIGMS NIH HHS R15 GM134457
6 · The paper itself

Abstract

Organophosphorus(V) fluorides have a long and tumultuous history, with early applications as toxins and nerve agents reflecting their poisonous past. Behind these very real safety considerations, there is also growing potential in a wide range of fields, from chemical biology to drug development. The recent inclusion of organophosphorus(V) fluorides in click chemistry exemplifies the promise these compounds possess and brings these molecules to the brink of a resurgence. In this Perspective, we delve into the history of P(V)-F compounds, discuss the precautions needed to work with them safely, and explore recent advancements in their synthesis and application. We conclude by discussing how this field can continue on a path toward innovation.

Indexed as

Chemical biologyClick chemistryFluorineOrganophosphorus compoundsPhosphorus fluoride exchange chemistrySynthetic methods

Identifiers

PMID38947532
PMCPMC11212144

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.