Evidence map›Paper›PMID 38947401›Full record

ReviewJournal of Cancer2024

Exosomes in Bone Cancer: Unveiling their Vital Role in Diagnosis, Prognosis, and Therapeutic Advancements.

Subhrojyoti Ghosh, Atharva Anand Mahajan, Anuvab Dey, Ramya Lakshmi Rajendran, Ankita Chowdhury, Sushmita Sen, Subhobrata Paul, Sourav Majhi, Chae Moon Hong, Prakash Gangadaran and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Exosomal ncRNAs in reproductive cancers†.Biology of reproduction · 2025
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Subhrojyoti GhoshDepartment of Biotechnology, Indian Institute of Technology Madras, Chennai, Tamil Nadu 600036, India.
Atharva Anand MahajanAdvanced Centre for Treatment, Research, and Education in Cancer, Tata Memorial Centre, Mumbai, Maharashtra 410210, India.
Anuvab DeyDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, North Guwahati, Assam 781039, India.
Ramya Lakshmi RajendranDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
Ankita ChowdhuryDepartment of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Delhi 110016, India.
Sushmita SenDepartment of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Delhi 110016, India.
Subhobrata PaulDepartment of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Delhi 110016, India.
Sourav MajhiDepartment of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Delhi 110016, India.
Chae Moon HongDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
Prakash GangadaranDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
Byeong-Cheol AhnDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
Anand KrishnanDepartment of Chemical Pathology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, 9300, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone cancer among adolescents and children exhibits varying survival outcomes based on disease state. While localized bone cancer cases have a survival rate exceeding 70%, metastatic, refractory, and recurrent forms are associated with significantly poorer prognoses. Initially believed to be mere vehicles for cellular waste disposal, exosomes are now recognized as extracellular vesicles facilitating intercellular communication. These vesicles influence cellular behaviors by transporting various biomolecules, such as proteins, DNA, RNA, and lipids, among cells. The role of exosomes in regulating the progression of bone cancer is increasingly evident, impacting critical processes like tumorigenesis, proliferation, metastasis, angiogenesis, immune evasion, and drug resistance. Current research underscores the substantial potential of exosomes in promoting the progression and development of bone cancer. This review delves into the complex process of exosome biogenesis, the variety of cell-derived exosome sources, and their applications in drug delivery and therapeutics. It also examines ongoing clinical trials focused on exosome cargo levels and discusses the challenges and future directions in exosome research. Unlike costly and invasive traditional diagnostic methods, exosomal biomarkers offer a non-invasive, cost-effective, and readily accessible routine screening through simple fluid collection that aims to inspire researchers to investigate the potential of exosomes for cancer theragnostic. Through comprehensive exploration of these areas, the review seeks to enhance understanding and foster innovative solutions to cancer biology in the near future.

Indexed as

BiomarkersBone cancerExosomesExtracellular vesiclesLiquid biopsyPrecision medicineTumor microenvironment

Identifiers

PMID38947401
PMCPMC11212077

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.