Evidence map›Paper›PMID 38947359›Full record

ArticleFrontiers in public health2024

Defining a screening tool for post-traumatic stress disorder in East Africa: a penalized regression approach.

Susan M Meffert, Muthoni A Mathai, Linnet Ongeri, Thomas C Neylan, Daniel Mwai, Dickens Onyango, Dickens Akena, Grace Rota, Ammon Otieno, Raymond R Obura and 14 more

Abstract read
In one paragraph

Article in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Susan M MeffertDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, United States.
Muthoni A MathaiDepartment of Psychiatry, University of Nairobi, Nairobi, Kenya.
Linnet OngeriKenya Medical Research Institute, Nairobi, Kenya.
Thomas C NeylanDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, United States.
Daniel MwaiDepartment of Health Economics, University of Nairobi, Nairobi, Kenya.
Dickens OnyangoKisumu County Ministry of Health, Kisumu, Kenya.
Dickens AkenaDepartment of Psychiatry, Makerere University, Kampala, Uganda.
Grace RotaDepartment of Psychiatry, Makerere University, Kampala, Uganda.
Ammon OtienoDepartment of Psychiatry, Makerere University, Kampala, Uganda.
Raymond R OburaGlobal Programs for Research and Training, Nairobi, Kenya.
Josline WangiaUniversity of Nairobi, Nairobi, Kenya.
Elizabeth OpiyoUniversity of Nairobi, Nairobi, Kenya.
Peter MuchembreGlobal Programs for Research and Training, Nairobi, Kenya.
Dennis OluochGlobal Programs for Research and Training, Nairobi, Kenya.
Raphael WamburaKisumu County Ministry of Health, Kisumu, Kenya.
Anne MbwayoDepartment of Psychiatry, University of Nairobi, Nairobi, Kenya.
James G KahnInstitute for Health Policy Studies, University of California, San Francisco, San Francisco, CA, United States.
Craig R CohenDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United States.
David E BukusiDepartment of Psychiatry, University of Nairobi, Nairobi, Kenya.
Gregory A AaronsDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Rachel L BurgerDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, United States.
Chengshi JinDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States.
Simon Njuguna KahongeKenya Ministry of Health, Nairobi, Kenya.

Funding

The SMART-DAPPER study: Implementation research on Tele-mental health care in the COVID19 eraR01MH113722 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MEFFERT, SUSAN M. · 2019 to 2023
$3.6M
Depression And Primary-care Partnership for Effectiveness-implementation Research (DAPPER)R01MH115512 · NIMH · UNIVERSITY OF NAIROBI · PI MATHAI, MUTHONI MUTHONI, MEFFERT, SUSAN M. · 2018 to 2022
$3.1M
NIMH NIH HHS R01 MH113722NIMH NIH HHS R01 MH115512
6 · The paper itself

Abstract

Background: Scalable PTSD screening strategies must be brief, accurate and capable of administration by a non-specialized workforce. Methods: We used PTSD as determined by the structured clinical interview as our gold standard and considered predictors sets of (a) Posttraumatic Stress Checklist-5 (PCL-5), (b) Primary Care PTSD Screen for the DSM-5 (PC-PTSD) and, (c) PCL-5 and PC-PTSD questions to identify the optimal items for PTSD screening for public sector settings in Kenya. A logistic regression model using LASSO was fit by minimizing the average squared error in the validation data. Area under the receiver operating characteristic curve (AUROC) measured discrimination performance. Results: Penalized regression analysis suggested a screening tool that sums the Likert scale values of two PCL-5 questions-intrusive thoughts of the stressful experience (#1) and insomnia (#21). This had an AUROC of 0.85 (using hold-out test data) for predicting PTSD as evaluated by the MINI, which outperformed the PC-PTSD. The AUROC was similar in subgroups defined by age, sex, and number of categories of trauma experienced (all AUROCs>0.83) except those with no trauma history- AUROC was 0.78. Conclusion: In some East African settings, a 2-item PTSD screening tool may outperform longer screeners and is easily scaled by a non-specialist workforce.

Indexed as

Mass ScreeningStress Disorders, Post-TraumaticAdolescentAdultFemaleHumansKenyaMaleMiddle AgedRegression AnalysisSurveys and QuestionnairesYoung AdultEast Africa (Kenya)low and middle income countries (LMIC)posttraumatic stress disorder (PTSD)primary carescreening toolssub Saharan Africatraumatic stress

Identifiers

PMID38947359
PMCPMC11211862

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.