Evidence map›Paper›PMID 38947220›Full record

ArticleBJA open2024

Cardiopulmonary exercise variables and their association with postoperative morbidity and mortality after major oesophagogastric cancer surgery-a multicentre observational study.

Malcolm A West, Saqib Rahman, Sandy Jack, Michael P W Grocott, Denny Z H Levett, Perioperative Exercise Testing and Training Society (POETTS), Yasir Rashid, John Griffiths, Martin Ezra, Lyndsay Ayres and 24 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJA open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03637647 (Cardiopulmonary Exercise Variables Are Associated With Postoperative Morbidity and Mortality After Major Oesophagogastric Cancer Surgery - A Multicentre Observational Study), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03637647 completednot on this map

Cardiopulmonary Exercise Variables Are Associated With Postoperative Morbidity and Mortality After Major Oesophagogastric Cancer Surgery - A Multicentre Observational Study

Typeobservational_patient_registrySponsorUniversity Hospital Southampton NHS Foundation TrustRan2012 to 2022Enrolled611ConditionsUpper Gastrointestinal DisordersArmsCardiopulmonary exercise testing
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Malcolm A WestSchool of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Saqib RahmanSchool of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Sandy JackPerioperative and Critical Care Theme, NIHR Southampton Biomedical Research Centre, University Hospital Southampton/University of Southampton, Southampton, UK.
Michael P W GrocottPerioperative and Critical Care Theme, NIHR Southampton Biomedical Research Centre, University Hospital Southampton/University of Southampton, Southampton, UK.
Denny Z H LevettPerioperative and Critical Care Theme, NIHR Southampton Biomedical Research Centre, University Hospital Southampton/University of Southampton, Southampton, UK.
Perioperative Exercise Testing and Training Society (POETTS)
Yasir RashidNuffield Department of Anaesthetics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
John GriffithsNuffield Department of Anaesthetics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Martin EzraNuffield Department of Anaesthetics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Lyndsay AyresDepartments of Anaesthesia and Critical Care, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Helen Neville-WebbeDepartments of Anaesthesia and Critical Care, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Muhammad Shafiq JavedDepartment of General Surgery, Aintree University Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Milind ShrotriDepartment of General Surgery, Aintree University Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Iftikhar KhanDepartment of General Surgery, Aintree University Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
David WhitmoreDepartments of Anaesthesia and Critical Care, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Pradeep PrabhuDepartment of Anaesthetics, The Royal Surrey Foundation NHS Trust, Guildford, UK.
David TimbrellDepartment of Anaesthetics, The Royal Surrey Foundation NHS Trust, Guildford, UK.
Sophie AllenDepartment of General Surgery, The Royal Surrey NHS Foundation Trust Hospital, Minimal Access Therapy Training Unit (MATTU), Guildford, UK.
Andrew O PackhamDepartment of Anaesthesia, University Hospitals of Leicester NHS Trust, Leicester, UK.
David SharpeDepartment of Gastro-Intestinal Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Helen AndersonDirectorate of Anaesthesia, University Hospitals Plymouth NHS Trust, Plymouth, UK.
Gary MintoDirectorate of Anaesthesia, University Hospitals Plymouth NHS Trust, Plymouth, UK.
Samuel McAleerDirectorate of Anaesthesia, University Hospitals Plymouth NHS Trust, Plymouth, UK.
Stuart McPhailDirectorate of Anaesthesia, University Hospitals Plymouth NHS Trust, Plymouth, UK.
Mohamed AlasmarSalford Royal NHS Foundation Trust, Salford Royal, Salford, UK.
Robert A HartleySalford Royal NHS Foundation Trust, Salford Royal, Salford, UK.
Javed SultanDepartment of General Surgery, The Royal Surrey NHS Foundation Trust Hospital, Minimal Access Therapy Training Unit (MATTU), Guildford, UK.
Ben GraceSchool of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Timothy J UnderwoodSchool of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
James ByrneUniversity Hospitals Southampton, Department of Surgery, Southampton, UK.
Fergus NobleUniversity Hospitals Southampton, Department of Surgery, Southampton, UK.
Jamie KellyUniversity Hospitals Southampton, Department of Surgery, Southampton, UK.
Gillian AnsellPerioperative and Critical Care Theme, NIHR Southampton Biomedical Research Centre, University Hospital Southampton/University of Southampton, Southampton, UK.
Mark EdwardsPerioperative and Critical Care Theme, NIHR Southampton Biomedical Research Centre, University Hospital Southampton/University of Southampton, Southampton, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Outcomes after oesophagogastric cancer surgery remain poor. Cardiopulmonary exercise testing (CPET) used for risk stratification before oesophagogastric cancer surgery is based on conflicting evidence. This study explores the relationship between CPET and postoperative outcomes, specifically for patients undergoing neoadjuvant treatment. Methods: Patients undergoing oesophagogastric cancer resection and CPET (pre- or post-neoadjuvant treatment, or both) were retrospectively enrolled into a multicentre pooled cohort study. Oxygen uptake at peak exercise (VO Results: Seven UK centres recruited 611 patients completing a 3-yr postoperative follow-up period. Oesophagectomy was undertaken in 475 patients (78%). Major complications occurred in 25%, with 18% 1-yr and 43% 3-yr mortality. No association between VO Conclusions: VO Clinical trial registration: NCT03637647.

Indexed as

cardiopulmonary exercise testingfitnessmorbiditymortalityneoadjuvant cancer treatmentsoesophagogastric cancertumour outcomes

Identifiers

PMID38947220
PMCPMC11214286

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.