Evidence map›Paper›PMID 38947124›Full record

ArticleFrontiers in cellular and infection microbiology2024

Temperatures above 37°C increase virulence of a convergent

Justus U Müller, Michael Schwabe, Lena-Sophie Swiatek, Stefan E Heiden, Rabea Schlüter, Max Sittner, Jürgen A Bohnert, Karsten Becker, Evgeny A Idelevich, Sebastian Guenther and 2 more

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The cycle of infectious fever - how it affects bacterial infections.Frontiers in cellular and infection microbiology · 2026
    Review
  3. Sugar Import SuppressesbioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Justus U MüllerDepartment of Epidemiology and Ecology of Antimicrobial Resistance, Helmholtz Institute for One Health, Helmholtz Centre for Infection Research (HZI), Greifswald, Germany.
Michael SchwabeDepartment of Epidemiology and Ecology of Antimicrobial Resistance, Helmholtz Institute for One Health, Helmholtz Centre for Infection Research (HZI), Greifswald, Germany.
Lena-Sophie SwiatekDepartment of Epidemiology and Ecology of Antimicrobial Resistance, Helmholtz Institute for One Health, Helmholtz Centre for Infection Research (HZI), Greifswald, Germany.
Stefan E HeidenDepartment of Epidemiology and Ecology of Antimicrobial Resistance, Helmholtz Institute for One Health, Helmholtz Centre for Infection Research (HZI), Greifswald, Germany.
Rabea SchlüterImaging Center of the Department of Biology, University of Greifswald, Greifswald, Germany.
Max SittnerDepartment of Epidemiology and Ecology of Antimicrobial Resistance, Helmholtz Institute for One Health, Helmholtz Centre for Infection Research (HZI), Greifswald, Germany.
Jürgen A BohnertFriedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
Karsten BeckerFriedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
Evgeny A IdelevichFriedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
Sebastian GuentherPharmaceutical Biology, Institute of Pharmacy, University of Greifswald, Greifswald, Germany.
Elias Eger *Department of Epidemiology and Ecology of Antimicrobial Resistance, Helmholtz Institute for One Health, Helmholtz Centre for Infection Research (HZI), Greifswald, Germany.
Katharina Schaufler *Department of Epidemiology and Ecology of Antimicrobial Resistance, Helmholtz Institute for One Health, Helmholtz Centre for Infection Research (HZI), Greifswald, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Convergence of Methods: Hypermucoviscosity, biofilm formation, and mortality rates in Results: Our results show a temperature-dependent switch above 37°C towards a hypermucoviscous phenotype, consistent with increased biofilm formation and Conclusion: This study not only elucidates the impact of elevated temperatures on hypermucoviscosity and virulence in convergent KP but also sheds light on previously unrecognized aspects of its adaptive behavior, underscoring its resilience to changing environments.

Indexed as

BiofilmsKlebsiella InfectionsKlebsiella pneumoniaeTemperatureAnimalsBacterial ProteinsGene Expression ProfilingHumansLarvaLepidopteraMothsPhenotypePlasmidsVirulenceVirulence FactorsViscosityBacterial ProteinsVirulence FactorshypermucoviscosityhypervirulenceK. pneumoniaeplasmid copy numbertemperature-dependent virulencetranscriptomics

Identifiers

PMID38947124
PMCPMC11211929

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.