Evidence map›Paper›PMID 38947047›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource.

Hugo Caffaratti, Ben Slater, Nour Shaheen, Ariane Rhone, Ryan Calmus, Michael Kritikos, Sukhbinder Kumar, Brian Dlouhy, Hiroyuki Oya, Tim Griffiths and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hugo CaffarattiDepartment of Neurosurgery, University of Iowa, Iowa City, IA, USA.
Ben SlaterBiosciences Institute, Newcastle University Medical School, Newcastle upon Tyne, UK.
Nour ShaheenDepartment of Neurosurgery, University of Iowa, Iowa City, IA, USA.
Ariane RhoneDepartment of Neurosurgery, University of Iowa, Iowa City, IA, USA.
Ryan CalmusDepartment of Neurosurgery, University of Iowa, Iowa City, IA, USA.
Michael KritikosDepartment of Neurosurgery, University of Iowa, Iowa City, IA, USA.
Sukhbinder KumarDepartment of Neurosurgery, University of Iowa, Iowa City, IA, USA.
Brian DlouhyDepartment of Neurosurgery, University of Iowa, Iowa City, IA, USA.ORCID 0000-0001-6724-688X
Hiroyuki OyaDepartment of Neurosurgery, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-1733-5478
Tim GriffithsDepartment of Neurosurgery, University of Iowa, Iowa City, IA, USA.ORCID 0000-0001-8066-4381
Aaron D BoesDepartment of Psychiatry, University of Iowa, Iowa City, IA, USA.
Nicholas TrappDepartment of Psychiatry, University of Iowa, Iowa City, IA, USA.
Marcus KaiserNIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0002-4654-3110
Jérôme SalletStem Cell and Brain Research Institute, INSERM U1208, University of Lyon, Lyon, France.
Matthew I BanksDepartment of Anesthesiology, University of Wisconsin at Madison, WI, USA.ORCID 0000-0002-1936-7529
Matthew A HowardDepartment of Neurosurgery, University of Iowa, Iowa City, IA, USA.
Mario ZanatyDepartment of Neurosurgery, University of Iowa, Iowa City, IA, USA.
Christopher I PetkovDepartment of Neurosurgery, University of Iowa, Iowa City, IA, USA.

Funding

Project 5: ComputationalP50MH109429 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI Michael Peter Milham · 2017 to 2026
$25.3M
HUMAN AUDITORY CORTEX PHYSIOLOGYR01DC004290 · NIDCD · UNIVERSITY OF IOWA · PI HOWARD, MATTHEW A. · 2000 to 2025
$13.7M
Laminar Circuit Motifs for Working Memory and Language Combinatorics: From Cells to SystemsU01NS137991 · NINDS · UNIVERSITY OF IOWA · PI Jeremy Greenlee, Christopher I Petkov · 2024 to 2026
$2.3M
NIDCD NIH HHS R01 DC004290NIMH NIH HHS P50 MH109429NINDS NIH HHS U01 NS137991
6 · The paper itself

Abstract

Low-intensity Transcranial Ultrasound Stimulation is a promising non-invasive technique for brain stimulation and focal neuromodulation. Research with humans and animal models has raised the possibility that TUS can be biased towards enhancing or suppressing neural function. Here, we first collate a set of hypotheses on the directionality of TUS effects and conduct an initial meta-analysis on available healthy human participant TUS studies reporting stimulation parameters and outcomes (

Indexed as

clinical applicationexcitationfocused ultrasound stimulationinhibitionlow intensityneuromodulationNon-invasive brain stimulationsuppression

Identifiers

PMID38947047
PMCPMC11213082

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.