Evidence map›Paper›PMID 38947021›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Molecular epidemiology of recurrent zoonotic transmission of mpox virus in West Africa.

Delia Doreen Djuicy, Ifeanyi F Omah, Edyth Parker, Christopher H Tomkins-Tinch, James Richard Otieno, Moïse Henri Moumbeket Yifomnjou, Loique Landry Messanga Essengue, Akeemat Opeyemi Ayinla, Ayotunde E Sijuwola, Muhammad I Ahmed and 51 more

Abstract readPreprint
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Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

61 authors.

Delia Doreen DjuicyVirology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274.
Ifeanyi F OmahInstitute of Ecology and Evolution, University of Edinburgh, The King's Buildings, Edinburgh EH9 3FL, UK.
Edyth ParkerAfrican Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Christopher H Tomkins-TinchThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
James Richard OtienoTheiagen Genomics, Highlands Ranch, CO, USA.
Moïse Henri Moumbeket YifomnjouVirology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274.
Loique Landry Messanga EssengueVirology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274.
Akeemat Opeyemi AyinlaAfrican Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Ayotunde E SijuwolaAfrican Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Muhammad I AhmedAfrican Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Oludayo O Ope-EweAfrican Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Olusola Akinola OgunsanyaAfrican Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Alhaji OlonoAfrican Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Philomena EromonAfrican Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Martial Gides Wansi YongaVirology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274.
Gael Dieudonné EssimaVirology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274.
Ibrahim Pascal TouoyemVirology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274.
Landry Jules Mouliem MounchiliVirology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274.
Sara Irene EyangohVirology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274.
Linda EssoDepartment for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaounde, Cameroon.
Inès Mandah Emah NguidjolDepartment for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaounde, Cameroon.
Steve Franck MetombDepartment for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaounde, Cameroon.
Cornelius CheboDepartment for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaounde, Cameroon.
Samuel Mbah AgweDepartment for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaounde, Cameroon.
Hans Makembe MossiDepartment for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaounde, Cameroon.
Chanceline Ndongo BiloungaDepartment for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaounde, Cameroon.
Alain Georges Mballa EtoundiVirology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274.
Olusola AkanbiNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Abiodun EgwuenuNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Odianosen EhiakhamenNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Chimaobi ChukwuNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Kabiru SuleimanNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Afolabi AkinpeluNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Adama AhmadNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Khadijah Isa ImamNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Richard OjedeleNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Victor OripenayeNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Kenneth IkeataNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Sophiyah AdelakunNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Babatunde OlajumokeNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Áine O'TooleInstitute of Ecology and Evolution, University of Edinburgh, The King's Buildings, Edinburgh EH9 3FL, UK.
Andrew MageeDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Mark ZellerDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Karthik GangavarapuDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Patrick VarillyThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Daniel J ParkThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Gerald MboowaAfrica Centres for Disease Control and Prevention (Africa CDC),Addis Ababa, Ethiopia.
Sofonias Kifle TessemaAfrica Centres for Disease Control and Prevention (Africa CDC),Addis Ababa, Ethiopia.
Yenew Kebede TebejeAfrica Centres for Disease Control and Prevention (Africa CDC),Addis Ababa, Ethiopia.
Onikepe FolarinAfrican Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Anise HappiAfrican Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Philippe LemeyDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
Marc A SuchardDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Kristian G AndersenDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Pardis SabetiThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Andrew RambautInstitute of Ecology and Evolution, University of Edinburgh, The King's Buildings, Edinburgh EH9 3FL, UK.
Chikwe IhekweazuNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Idriss JideNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Ifedayo AdetifaNigeria Centre for Disease Control and Prevention., Abuja, Nigeria.
Richard NjoumVirology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274.
Christian T HappiAfrican Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI NEAFSEY, DANIEL E · 2014 to 2024
$66.5M
Technology CoreU19AI135995 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Bryan Briney · 2018 to 2026
$32.0M
West African Emerging Infectious Disease Research Center (WA-EIDRC)U01AI151812 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ANDERSEN, KRISTIAN GRAUGAARD, GARRY, ROBERT F · 2020 to 2024
$13.2M
Utilize Microbial Metagenomics for Viral Pathogen CharacterizationU54HG007480 · NHGRI · REDEEMER'S UNIVERSITY · PI HAPPI, CHRISTIAN T. · 2017 to 2022
$5.5M
Fast and flexible Bayesian phylogenetics via modern machine learningR01AI162611 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MATSEN, FREDERICK ALBERT · 2021 to 2025
$3.8M
Statistical Innovation to Integrate Sequences and Phenotypes for Scalable Phylodynamic InferenceR01AI153044 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Marc A. Suchard · 2021 to 2026
$2.4M
Host and Microbial Genetic Determinants of Febrile Illness in West AfricaU01HG007480 · NHGRI · REDEEMER'S UNIVERSITY · PI HAPPI, CHRISTIAN T. · 2013 to 2016
$1.6M
NHGRI NIH HHS U01 HG007480NHGRI NIH HHS U54 HG007480NIAID NIH HHS R01 AI153044NIAID NIH HHS R01 AI162611NIAID NIH HHS U01 AI151812NIAID NIH HHS U19 AI110818NIAID NIH HHS U19 AI135995Wellcome Trust
6 · The paper itself

Abstract

Nigeria and Cameroon reported their first mpox cases in over three decades in 2017 and 2018 respectively. The outbreak in Nigeria is recognised as an ongoing human epidemic. However, owing to sparse surveillance and genomic data, it is not known whether the increase in cases in Cameroon is driven by zoonotic or sustained human transmission. Notably, the frequency of zoonotic transmission remains unknown in both Cameroon and Nigeria. To address these uncertainties, we investigated the zoonotic transmission dynamics of the mpox virus (MPXV) in Cameroon and Nigeria, with a particular focus on the border regions. We show that in these regions mpox cases are still driven by zoonotic transmission of a newly identified Clade IIb.1. We identify two distinct zoonotic lineages that circulate across the Nigeria-Cameroon border, with evidence of recent and historic cross border dissemination. Our findings support that the complex cross-border forest ecosystems likely hosts shared animal populations that drive cross-border viral spread, which is likely where extant Clade IIb originated. We identify that the closest zoonotic outgroup to the human epidemic circulated in southern Nigeria in October 2013. We also show that the zoonotic precursor lineage circulated in an animal population in southern Nigeria for more than 45 years. This supports findings that southern Nigeria was the origin of the human epidemic. Our study highlights the ongoing MPXV zoonotic transmission in Cameroon and Nigeria, underscoring the continuous risk of MPXV (re)emergence.

Identifiers

PMID38947021
PMCPMC11213044

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.