Evidence map›Paper›PMID 38947015›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Alzheimer's disease CSF biomarkers correlate with early pathology and alterations in neuronal and glial gene expression.

Ali S Ropri, Tiffany G Lam, Vrinda Kalia, Heather M Buchanan, Anne Marie W Bartosch, Elliot H H Youth, Harrison Xiao, Sophie K Ross, Anu Jain, Jayanta K Chakrabarty and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Ali S RopriDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Tiffany G LamDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Vrinda KaliaDept. of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Heather M BuchananDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Anne Marie W BartoschDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Elliot H H YouthDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Harrison XiaoDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Sophie K RossDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Anu JainQuantitative Proteomics and Metabolomics Center, Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Jayanta K ChakrabartyQuantitative Proteomics and Metabolomics Center, Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Min Suk KangTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.
Deborah BoyettDepartment of Neurosurgery, Columbia University, New York, NY 10032, USA.
Eleonora F SpinazziDepartment of Neurosurgery, Columbia University, New York, NY 10032, USA.
Gail IodiceAnkyra Therapeutics, Cambridge, MA 02142, USA.
Robert A McGovernDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.
Lawrence S HonigTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.
Lewis M BrownQuantitative Proteomics and Metabolomics Center, Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Gary W MillerDept. of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Guy M McKhannDepartment of Neurosurgery, Columbia University, New York, NY 10032, USA.
Andrew F TeichDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-1916-8490

Funding

Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ADAM M BRICKMAN · 2020 to 2026
$30.1M
An investigation of Alzheimer's Disease pathology, microglial immune response, and CSF proteomics in normal pressure hydrocephalus patientsR01AG073360 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MCKHANN, GUY M, TEICH, ANDREW FRANKLIN · 2021 to 2025
$4.2M
An integrative analysis of DNA methylation, transcriptomic changes, and cognitive dysfunction in Alzheimer's diseaseK76AG054868 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TEICH, ANDREW FRANKLIN · 2016 to 2018
$633k
A systems approach to DNA methylation, gene expression, and cognitive dysfunction in Alzheimer's diseaseK08AG049938 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TEICH, ANDREW FRANKLIN · 2015 to 2016
$254k
NIA NIH HHS K08 AG049938NIA NIH HHS K76 AG054868NIA NIH HHS P30 AG066462NIA NIH HHS R01 AG073360
6 · The paper itself

Abstract

introductionNormal pressure hydrocephalus (NPH) patients undergoing cortical shunting frequently show early AD pathology on cortical biopsy, which is predictive of progression to clinical AD. The objective of this study was to use samples from this cohort to identify CSF biomarkers for AD-related CNS pathophysiologic changes using tissue and fluids with early pathology, free of post-mortem artifact.

methodsWe analyzed Simoa, proteomic, and metabolomic CSF data from 81 patients with previously documented pathologic and transcriptomic changes.

resultsAD pathology on biopsy correlates with CSF β-amyloid-40/42, neurofilament light chain (NfL), and phospho-tau-181(p-tau181)/β-amyloid-42, while several gene expression modules correlate with NfL. Proteomic analysis highlights 7 core proteins that correlate with pathology and gene expression changes on biopsy, and metabolomic analysis of CSF identifies disease-relevant groups that correlate with biopsy data.. DISCUSSION: As additional biomarkers are added to AD diagnostic panels, our work provides insight into the CNS pathophysiology these markers are tracking.

Indexed as

Alzheimer’s diseasebiomarkersCSFmetabolomicsproteomics

Identifiers

PMID38947015
PMCPMC11213077

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.